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Sesquiterpenoids and a steroid from the algicolous Trichoderma brevicompactum

文献类型：期刊论文

作者Shi, Zhen-Zhen2; Liu, Xiang-Hong1,2; Song, Yin-Ping2; Yin, Xiu-Li2; Ji, Nai-Yun2
刊名FITOTERAPIA
出版日期2021-09-01
卷号153页码:5
关键词Trichoderma Sesquiterpenoid Bisabolane Acorane Acyclic sesquiterpenoid Steroid
ISSN号0367-326X
DOI10.1016/j.fitote.2021.104983
通讯作者Ji, Nai-Yun(nyji@yic.ac.cn)
英文摘要Six new sesquiterpenoids including three bisabolane derivatives, trichobisabolins O-1, O-2, and P (1-3), two nerolidol derivatives, trichonerolins A and B (4 and 5), one acorane, trichoacorin A (6), along with one new steroid, isoergokonin B (7), were isolated from the culture of Trichoderma brevicompactum A-DL-9-2 obtained from the inner tissue of the red alga Chondria tenuissima. Their structures and relative configurations were assigned by interpretation of 1D/2D NMR and MS data. As acyclic sesquiterpenoids, compounds 4 and 5 were discovered from Trichoderma for the first time. Compounds 1-7 were evaluated for the inhibition of some marine derived organisms, in which, 3 and 4/5 exhibited potent inhibition against Amphidinium carterae and Chattonella marina with IC50 of 1.8 mu g/mL and 1.2 mu g/mL, respectively. In addition, compound 7 could inhibit the growth of Pseudoalteromonas citrea with an MIC value of 64 mu g/mL.
WOS关键词MARINE ; ANTIFUNGAL
资助项目Natural Science Foundation of Shandong Province[ZR2020QD102] ; Natural Science Foundation of Shandong Province[ZR2020QC002] ; National Natural Science Foundation of China[42076096] ; Taishan Scholar Project[tsqn201909164]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000684861800026
资助机构Natural Science Foundation of Shandong Province ; National Natural Science Foundation of China ; Taishan Scholar Project
源URL[http://ir.yic.ac.cn/handle/133337/29646]  
专题海岸带生物资源高效利用研究与发展中心
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者Ji, Nai-Yun
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Ctr Ocean Mega Sci, Yantai 264003, Peoples R China
推荐引用方式
GB/T 7714		 Shi, Zhen-Zhen,Liu, Xiang-Hong,Song, Yin-Ping,et al. Sesquiterpenoids and a steroid from the algicolous Trichoderma brevicompactum[J]. FITOTERAPIA,2021,153:5.
APA Shi, Zhen-Zhen,Liu, Xiang-Hong,Song, Yin-Ping,Yin, Xiu-Li,&Ji, Nai-Yun.(2021).Sesquiterpenoids and a steroid from the algicolous Trichoderma brevicompactum.FITOTERAPIA,153,5.
MLA Shi, Zhen-Zhen,et al."Sesquiterpenoids and a steroid from the algicolous Trichoderma brevicompactum".FITOTERAPIA 153(2021):5.

入库方式： OAI收割

来源：烟台海岸带研究所

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