中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 海岸带生物学与生物资源利用重点实验室
  5. 海岸带生物资源高效利用研究与发展中心
Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops

文献类型：期刊论文

作者Song, Junlin2; Wang, Chunde1,2
刊名GENOMICS
出版日期2021-07-01
卷号113期号:4页码:2839-2846
关键词Transcriptomic VPS29 Carotenoid deposition mRNA
ISSN号0888-7543
DOI10.1016/j.ygeno.2021.06.015
通讯作者Wang, Chunde(chundewang2007@163.com)
英文摘要Background: In our previous studies, we demonstrated that the accumulation of carotenoids in QN Orange scallops might be regulated by the vacuolar protein sorting 29 (VPS29) gene. VPS genes are involved in pigments accumulation (including carotenoids) in some species and VPS29 is known as the core component of the membrane transport complex Retromer. However, the possible mechanism of carotenoids accumulation underlying the VPS29 remains unexplored. This study aimed to further elucidate the roles of VPS29 in the carotenoid deposition. Results: Transcriptomic analyses revealed four differentially expressed genes related to carotenoid accumulation, including three down-regulated genes, low-density lipoprotein receptor domain class, scavenger receptor, Niemann Pick C1-like 1, and one up-regulated gene, ATP binding cassette transporter in RNAi group. Results from metabonomic analyses indicated increased profiles of retinol and decreased fatty acids between the RNAi and the control group. Conclusions: It thus speculated that VPS may be related to the accumulation of carotenoids as RNAi of VPS 29 seemed to result in a reduction in pectenolone through the blockage in the absorption of carotenoids and an accelerated cleavage of carotenoids into retinol.
WOS关键词BOHAI RED ; TRANSPORTERS ; EXPRESSION ; RECEPTOR ; CELLS
资助项目National Natural Science Foundation[3197210450] ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province[2020LZGC016] ; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System[SDAIT-14] ; Qingdao Agricultural University Foundation[663-1119015] ; Shandong Province Natural Science Foundation[ZR2020QC203]
WOS研究方向Biotechnology & Applied Microbiology ; Genetics & Heredity
语种英语
WOS记录号WOS:000669212300002
资助机构National Natural Science Foundation ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province ; Earmarked Fund for Shandong Modern Agro-Industry Technology Research System ; Qingdao Agricultural University Foundation ; Shandong Province Natural Science Foundation
源URL[http://ir.yic.ac.cn/handle/133337/29481]  
专题海岸带生物资源高效利用研究与发展中心
通讯作者Wang, Chunde
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China
2.Qingdao Agr Univ, Qingdao 266109, Peoples R China
推荐引用方式
GB/T 7714		 Song, Junlin,Wang, Chunde. Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops[J]. GENOMICS,2021,113(4):2839-2846.
APA Song, Junlin,&Wang, Chunde.(2021).Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops.GENOMICS,113(4),2839-2846.
MLA Song, Junlin,et al."Transcriptomic and metabonomic analyses reveal roles of VPS 29 in carotenoid accumulation in adductor muscles of QN Orange scallops".GENOMICS 113.4(2021):2839-2846.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。