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Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)

文献类型：期刊论文

作者Kuang, Weimin11; Hu, Jingyang11; Wu, Hong11; Fen, Xiaotian8,9,10; Dai, Qingyan8,9,10; Fu, Qiaomei8,9,10; Xiao, Wen7; Frantz, Laurent5,6; Roos, Christian4; Nadler, Tilo
刊名FRONTIERS IN GENETICS
出版日期2020-12-15
卷号11页码:10
关键词snub-nosed monkeys population genomics genetic diversity inbreeding genetic load population decline
DOI10.3389/fgene.2020.615926
通讯作者Yu, Li(yuli@ynu.edu.cn)
英文摘要The snub-nosed monkey genus (Rhinopithecus) comprises five closely related species (R. avunculus, R. bieti, R. brelichi, R. roxellana, and R. strykeri). All are among the world's rarest and most endangered primates. However, the genomic impact associated with their population decline remains unknown. We analyzed population genomic data of all five snub-nosed monkey species to assess their genetic diversity, inbreeding level, and genetic load. For R. roxellana, R. bieti, and R. strykeri, population size is positively correlated with genetic diversity and negatively correlated with levels of inbreeding. Other species, however, which possess small population sizes, such as R. brelichi and R. avunculus, show high levels of genetic diversity and low levels of genomic inbreeding. Similarly, in the three populations of R. roxellana, the Shennongjia population, which possesses the lowest population size, displays a higher level of genetic diversity and lower level of genomic inbreeding. These findings suggest that although R. brelichi and R. avunculus and the Shennongjia population might be at risk, it possess significant genetic diversity and could thus help strengthen their long-term survival potential. Intriguingly, R. roxellana with large population size possess high genetic diversity and low level of genetic load, but they show the highest recent inbreeding level compared with the other snub-nosed monkeys. This suggests that, despite its large population size, R. roxellana has likely been experiencing recent inbreeding, which has not yet affected its mutational load and fitness. Analyses of homozygous-derived deleterious mutations identified in all snub-nosed monkey species indicate that these mutations are affecting immune, especially in smaller population sizes, indicating that the long-term consequences of inbreeding may be resulting in an overall reduction of immune capability in the snub-nosed monkeys, which could provide a dramatic effect on their long-term survival prospects. Altogether, our study provides valuable information concerning the genomic impact of population decline of the snub-nosed monkeys. We revealed multiple counterintuitive and unexpected patterns of genetic diversity in small and large population, which will be essential for conservation management of these endangered species.
WOS关键词POPULATION DECLINE ; MITOCHONDRIAL-DNA ; GENOME ; CONSERVATION ; ROXELLANA ; PRIMATES ; PHYLOGEOGRAPHY ; HOMOZYGOSITY ; EXTINCTION ; FRAMEWORK
资助项目National Natural Science Foundation of China[31925006] ; Yunnan University's Research Innovation Fund for Graduate Students[2019z050] ; Academic Graduate Students Foundation of Yunnan Province
WOS研究方向Genetics & Heredity
语种英语
出版者FRONTIERS MEDIA SA
WOS记录号WOS:000603613500001
资助机构National Natural Science Foundation of China ; Yunnan University's Research Innovation Fund for Graduate Students ; Academic Graduate Students Foundation of Yunnan Province
源URL[http://119.78.100.205/handle/311034/18725]  
专题中国科学院古脊椎动物与古人类研究所
通讯作者Yu, Li
作者单位1.Lushui Forestry & Grassland Council, Nujiang, Peoples R China
2.Gaoligong Mt Natl Nat Reserve, Lushui Management & Conservat Branch, Nujiang, Peoples R China
3.Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
4.Leibniz Inst Primate Res, German Primate Ctr, Gene Bank Primates & Primate Genet Lab, Gottingen, Germany
5.Univ Oxford, Dept Archaeol, Palaeogen & Bioarchaeol Res Network, Oxford, England
6.Queen Mary Univ London, Sch Biol & Chem Sci, London, England
7.Dali Univ, Inst Eastern Himalaya Biodivers Res, Dali, Peoples R China
8.Univ Chinese Acad Sci, Beijing Coll Life Sci, Beijing, Peoples R China
9.Chinese Acad Sci, Ctr Excellence Life & Paleoenvironm, Beijing, Peoples R China
10.Chinese Acad Sci, Key Lab Vertebrate Evolut & Human Origins, CAS, IVPP, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Kuang, Weimin,Hu, Jingyang,Wu, Hong,et al. Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)[J]. FRONTIERS IN GENETICS,2020,11:10.
APA Kuang, Weimin.,Hu, Jingyang.,Wu, Hong.,Fen, Xiaotian.,Dai, Qingyan.,...&Yu, Li.(2020).Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus).FRONTIERS IN GENETICS,11,10.
MLA Kuang, Weimin,et al."Genetic Diversity, Inbreeding Level, and Genetic Load in Endangered Snub-Nosed Monkeys (Rhinopithecus)".FRONTIERS IN GENETICS 11(2020):10.

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来源：古脊椎动物与古人类研究所

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