African lungfish genome sheds light on the vertebrate water-to-land transition
文献类型：期刊论文
| 作者 | Wang, Kun18; Wang, Jun16,17; Zhu, Chenglong15,18; Yang, Liandong14; Ren, Yandong15,18; Ruan, Jue13; Fan, Guangyi11,12; Hu, Jiang10; Xu, Wenjie18; Bi, Xupeng11 |
| 刊名 | CELL
 |
| 出版日期 | 2021-03-04 |
| 卷号 | 184期号:5页码:1-15 |
| ISSN号 | 0092-8674 |
| DOI | 10.1016/j.cell.2021.01.047 |
| 英文摘要 | Lungfishes are the closest extant relatives of tetrapods and preserve ancestral traits linked with the water-to-land transition. However, their huge genome sizes have hindered understanding of this key transition in evolution. Here, we report a 40-Gb chromosome-level assembly of the African lungfish (Protopterus annectens) genome, which is the largest genome assembly ever reported and has a contig and chromosome N50 of 1.60 Mb and 2.81 Gb, respectively. The large size of the lungfish genome is due mainly to retrotransposons. Genes with ultra-long length show similar expression levels to other genes, indicating that lungfishes have evolved high transcription efficacy to keep gene expression balanced. Together with transcriptomeand experimental data, we identified potential genes and regulatory elements related to such terrestrial adaptation traits as pulmonary surfactant, anxiolytic ability, pentadactyl limbs, and pharyngeal remodeling. Our results provide insights and key resources for understanding the evolutionary pathway leading from fishes to humans. |
| 资助项目 | Fish10K project ; Strategic Priority Research Program of CAS[XDB13000000] ; 1000 Talent Project of Shaanxi Province ; Research Funds for Interdisciplinary Subject, NWPU[19SH030408] ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Youth Innovation Promotion Association of the CAS ; NSFC of China[41876179] ; NSFC of China[31972866] ; Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2018) ; National Key Research and Development Program of China[2018YFD0900604] ; Villum Foundation[25900] ; Frasergen Bioinformatics Co., Ltd. |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| 出版者 | CELL PRESS |
| WOS记录号 | WOS:000629635700021 |
| 源URL | [http://119.78.100.205/handle/311034/18564]  |
| 专题 | 古脊椎动物与古人类研究所_图书馆1 |
| 通讯作者 | Zhao, Wenming; Qiu, Qiang; He, Shunping; Wang, Wen |
| 作者单位 | 1.Northwestern Polytech Univ, Xian 710072, Peoples R China 2.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China 3.Univ Copenhagen, Villum Ctr Biodivers Genom, Dept Biol, Sect Ecol & Evolut, Copenhagen, Denmark 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 5.Southwest Univ, Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev, Chongqing 400715, Peoples R China 6.China Natl Ctr Bioinformat, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China 8.Northwest A&F Univ, Coll Vet Med, Dept Clin Vet Med, Key Lab Anim Biotechnol,Minist Agr, Yangling 712100, Shaanxi, Peoples R China 9.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 10.Grand Biosci, Beijing 102200, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Kun,Wang, Jun,Zhu, Chenglong,et al. African lungfish genome sheds light on the vertebrate water-to-land transition[J]. CELL,2021,184(5):1-15. |
| APA | Wang, Kun.,Wang, Jun.,Zhu, Chenglong.,Yang, Liandong.,Ren, Yandong.,...&Wang, Wen.(2021).African lungfish genome sheds light on the vertebrate water-to-land transition.CELL,184(5),1-15. |
| MLA | Wang, Kun,et al."African lungfish genome sheds light on the vertebrate water-to-land transition".CELL 184.5(2021):1-15. |
入库方式： OAI收割
来源：古脊椎动物与古人类研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。