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  2. 地质与地球物理研究所
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  4. 中国科学院地球与行星物理重点实验室
Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition

文献类型：期刊论文

作者Zhang, Bingfang1,4,5; Wang, Lei3,4; Zhan, Aisheng1,4,5; Wang, Min3; Tian, Lanxiang1,2,5; Guo, Weixiang3,4; Pan, Yongxin1,2,4,5
刊名NATURE COMMUNICATIONS
出版日期2021-02-19
卷号12期号:1页码:17
ISSN号2041-1723
DOI10.1038/s41467-021-21468-x
英文摘要Adult hippocampal neurogenesis contributes to learning and memory, and is sensitive to a variety of environmental stimuli. Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. However, whether HMF exposure affect adult hippocampal neurogenesis and hippocampus-dependent cognitions is still an enigma. Here, we showed that male C57BL/6J mice exposed to HMF by means of near elimination of the geomagnetic field (GMF) exhibit significant impairments of adult hippocampal neurogenesis and hippocampus-dependent learning, which is strongly correlated with a reduction in the content of reactive oxygen species (ROS). However, these deficits seen in HMF-exposed mice could be rescued either by elevating ROS levels through pharmacological inhibition of ROS removal or by returning them back to GMF. Therefore, our results suggest that GMF plays an important role in adult hippocampal neurogenesis through maintaining appropriate endogenous ROS levels. Exposure to a hypomagnetic field (HMF) influences the cognitive processes of various animals, from insects to human beings. The authors show that in mice exposed to HMF, adult hippocampal neurogenesis and hippocampusdependent learning are impaired and could be rescued by restoring ROS levels.
资助项目NSFC[41621004] ; NSFC[31921002] ; NSFC[31771123] ; NSFC[41674071] ; National Key Research and Development Program of China[2019YFA080210] ; CAS Strategic Priority Research Program[XDB18010203] ; CAS Strategic Priority Research Program[XDA17010501] ; CAS Key Research Program of Frontier Sciences[QYZDJ-SSW-DQC024] ; CAS Key Research Program of Frontier Sciences[QYZDB-SSW-SMC046] ; Beijing Municipal Science & Technology Commission[Z181100001518001]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE RESEARCH
WOS记录号WOS:000621492700004
资助机构NSFC ; NSFC ; NSFC ; NSFC ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; NSFC ; NSFC ; NSFC ; NSFC ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; NSFC ; NSFC ; NSFC ; NSFC ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; NSFC ; NSFC ; NSFC ; NSFC ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Strategic Priority Research Program ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; CAS Key Research Program of Frontier Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission ; Beijing Municipal Science & Technology Commission
源URL[http://ir.iggcas.ac.cn/handle/132A11/100120]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者Tian, Lanxiang; Guo, Weixiang
作者单位1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Biogeomagnetism Grp, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Geol & Geophys, Paleomagnetism & Geochronol Lab, Beijing, Peoples R China
3.Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Mol & Dev Biol, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Innovat Acad Earth Sci, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Zhang, Bingfang,Wang, Lei,Zhan, Aisheng,et al. Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition[J]. NATURE COMMUNICATIONS,2021,12(1):17.
APA Zhang, Bingfang.,Wang, Lei.,Zhan, Aisheng.,Wang, Min.,Tian, Lanxiang.,...&Pan, Yongxin.(2021).Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition.NATURE COMMUNICATIONS,12(1),17.
MLA Zhang, Bingfang,et al."Long-term exposure to a hypomagnetic field attenuates adult hippocampal neurogenesis and cognition".NATURE COMMUNICATIONS 12.1(2021):17.

入库方式： OAI收割

来源：地质与地球物理研究所

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