中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia

文献类型:期刊论文

作者Zhang, Yi-jing6,7; Pu, Cheng-cheng5; Wang, Yong-ming3,4,6,7; Zhang, Rui-ting6,7; Cai, Xin-lu3,4,6,7; Zhou, Shu-zhe5; Ma, Yan-tao5; Wang, Yi6,7; Cheung, Eric F. C.2; Lui, Simon S. Y.1,2
刊名SCHIZOPHRENIA RESEARCH
出版日期2021-06-01
卷号232页码:77-84
通讯作者邮箱yuxin@bjmu.edu.cn (x. yu) ; rckchan@psych.ac.cn (r.c.k. chan)
ISSN号0920-9964
关键词Social brain network Social network Network analysis Schizophrenia Social anhedonia
DOI10.1016/j.schres.2021.05.016
产权排序1
文献子类实证研究
英文摘要

Social behaviour requires the brain to efficiently integrate multiple social processes, but it is not clear what neural substrates underlie general social behaviour. While psychosis patients and individuals with subclinical symptoms are characterized by social dysfunction, the neural mechanisms underlying social dysfunctions in schizophrenia spectrum disorders remains unclear. We first constructed a general social brain network (SBN) using resting state functional connectivity (FC) with regions of interest based on the automatic meta-analysis results from NeuroSynth. We then examined the general SBN and its relationship with social network (SN) characteristics in 30 individuals with schizophrenia (SCZ) and 33 individuals with social anhedonia (SA). We found that patients with SCZ exhibited deficits in their SN, while SA individuals did not. SCZ patients showed decreased segregation and functional connectivity in their SBN, while SA individuals showed a reversed pattern with increased segregation and functional connectivity of their SBN. Sparse canonical correlation analysis showed that both SCZ patients and SA individuals exhibited reduced correlation between SBN and SN characteristics compared with their corresponding healthy control groups. These preliminary findings suggest that both SCZ and SA participants exhibit abnormality in segregation and functional connectivity within the general SBN and reduced correlation with SN characteristics. These findings could guide the development of non-pharmacological interventions for social dysfunction in SCZ spectrum disorders. (c) 2021 Elsevier B.V. All rights reserved.

收录类别SCI
WOS关键词COGNITIVE DEFICITS ; SIZE ; AMYGDALA ; CONNECTIVITY ; ACTIVATION ; METAANALYSIS ; DYSFUNCTION ; STRESS ; SCALE
资助项目National Key Research and Development Programme[2016YFC0906402] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for Leading Talents in ST[Z151100000315020] ; CAS Key Laboratory of Mental Health, Institute of Psychology
WOS研究方向Psychiatry
出版者ELSEVIER
WOS记录号WOS:000664034300013
源URL[http://ir.psych.ac.cn/handle/311026/39810]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Yu, Xin; Chan, Raymond C. K.
作者单位1.Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China
2.Castle Peak Hosp, Hong Kong, Peoples R China
3.Sino Danish Ctr Educ & Res, Beijing, Peoples R China
4.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
5.Peking Univ, Hosp 6, Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
7.Chinese Acad Sci, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yi-jing,Pu, Cheng-cheng,Wang, Yong-ming,et al. Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia[J]. SCHIZOPHRENIA RESEARCH,2021,232:77-84.
APA Zhang, Yi-jing.,Pu, Cheng-cheng.,Wang, Yong-ming.,Zhang, Rui-ting.,Cai, Xin-lu.,...&Chan, Raymond C. K..(2021).Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia.SCHIZOPHRENIA RESEARCH,232,77-84.
MLA Zhang, Yi-jing,et al."Social brain network correlates with real-life social network in individuals with schizophrenia and social anhedonia".SCHIZOPHRENIA RESEARCH 232(2021):77-84.

入库方式: OAI收割

来源:心理研究所

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