Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia
文献类型：期刊论文
| 作者 | Wu, Zhi Wei5,6; Yu, Hong Hua4; Wang, Xuan3; Guan, Heng Yong3; Xiu, Mei Hong2; Zhang, Xiang Yang1 |
| 刊名 | PSYCHOSOMATIC MEDICINE
 |
| 出版日期 | 2021-06-01 |
| 卷号 | 83期号:5页码:485-491 |
| 关键词 | schizophrenia cytokine oxidative stress interactive effect clinical symptoms executive function |
| ISSN号 | 0033-3174 |
| DOI | 10.1097/PSY.0000000000000931 |
| 通讯作者 | Xiu, Mei Hong(xiumeihong97@163.com) ; Zhang, Xiang Yang(zhangxy9@gmail.com) |
| 英文摘要 | Objective Accumulating evidence has demonstrated that the pathophysiology of schizophrenia is involved in various abnormalities in oxidative stress markers and cytokines closely related to synaptic plasticity. However, the interactive effects among key cytokines, oxidative stress, and executive dysfunction and symptoms of schizophrenia have not been investigated yet. Methods A total of 189 patients with chronic schizophrenia and 60 controls were recruited in the current study. Tumor necrosis factor alpha (TNF-alpha), interleukin (IL)-8, IL-6, and IL-2 levels; catalase, glutathione peroxidase, and superoxide dismutase (SOD) activities; and malondialdehyde (MDA) levels were determined in patients and controls. Executive function was evaluated by the Wisconsin card sorting tests, the verbal fluency tests, and the Stroop word-color test. Clinical symptoms were evaluated by the Positive and Negative Syndrome Scale. Results Relative to the controls, the patients had lower activities of SOD and glutathione peroxidase and levels of TNF-alpha, but higher levels of MDA, IL-8, IL-6, and IL-2 (all p values < .05). A significant negative relationship between SOD activity and IL-8 levels was found only in patients (beta = -0.44, p = .008). Furthermore, we found that an interactive effect of low TNF-alpha level and high MDA level was associated with negative symptoms (beta = -0.02, p = .01). Moreover, the interactive effects of IL-8 and MDA or IL-8 and SOD were correlated with executive function only in patients (beta = 0.23, p = .02; beta = 0.09, p = .03). Conclusions Our findings suggest that the interrelationships between oxidative stress markers and cytokines occur in schizophrenia patients, which may be the basis of their pathological mechanisms underlying clinical symptoms and cognitive dysfunction. |
| 收录类别 | SCI |
| WOS关键词 | ANTIOXIDANT DEFENSE SYSTEMS ; 1ST EPISODE PSYCHOSIS ; NECROSIS-FACTOR-ALPHA ; PREFRONTAL CORTEX ; FREE-RADICALS ; CEREBROSPINAL-FLUID ; LIPID-PEROXIDATION ; NEGATIVE SYMPTOMS ; BIPOLAR DISORDER ; DOUBLE-BLIND |
| 资助项目 | National Natural Science Foundation of China[81371477] ; National Natural Science Foundation of China[81000509] ; Shenzhen Found for Guangdong Provincial High-level Clinical Key Specialties[SZGSP013] ; Sanming Project of Medicine in Shenzhen[SZSM201812052] |
| WOS研究方向 | Psychiatry ; Psychology |
| 语种 | 英语 |
| WOS记录号 | WOS:000669432500012 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 源URL | [http://ir.psych.ac.cn/handle/311026/39825]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Xiu, Mei Hong; Zhang, Xiang Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Peking Univ, HuiLongGuan Clin Med Sch, Beijing HuiLongGuan Hosp, Psychiat Res Ctr, Beijing, Peoples R China 3.Hebei Prov Rong Jun Hosp, Dept Psychiat, Baoding, Peoples R China 4.Yantai Automobile Engn Profess Coll, Yantai, Peoples R China 5.Shenzhen Mental Hlth Ctr, Shenzhen, Guangdong, Peoples R China 6.Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zhi Wei,Yu, Hong Hua,Wang, Xuan,et al. Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia[J]. PSYCHOSOMATIC MEDICINE,2021,83(5):485-491. |
| APA | Wu, Zhi Wei,Yu, Hong Hua,Wang, Xuan,Guan, Heng Yong,Xiu, Mei Hong,&Zhang, Xiang Yang.(2021).Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia.PSYCHOSOMATIC MEDICINE,83(5),485-491. |
| MLA | Wu, Zhi Wei,et al."Interrelationships Between Oxidative Stress, Cytokines, and Psychotic Symptoms and Executive Functions in Patients With Chronic Schizophrenia".PSYCHOSOMATIC MEDICINE 83.5(2021):485-491. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。