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Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia

文献类型：期刊论文

作者Hu, Jinghan7; Zhou, Yongjie6; Wang, Ruoxi5; Qi, Ling4; Zhou, Xin3; Song, Xiuli2; Zeng, Lingyun6; Zhang, Xiangyang1
刊名ASIAN JOURNAL OF PSYCHIATRY
出版日期2021-08-01
卷号62页码:5
ISSN号1876-2018
关键词Adolescence Schizophrenia Glycometabolism First-episode drug-naive Psychopathology
DOI10.1016/j.ajp.2021.102716
通讯作者Zhou, Yongjie(qingzhu1108@126.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn)
英文摘要Extensive studies have reported alterations in glucose metabolism in adult-onset patients with schizophrenia, but less attention has been paid to adolescent-onset patients with first-episode drug-naive (FEDN) schizophrenia. The purpose of this study was to compare glucose metabolism between adolescent-onset patients with FEDN schizophrenia and healthy controls and to investigate the relationship between glucose metabolism and clinical symptoms in patients with schizophrenia. This study compared the glycometabolism parameters between 51 adolescents-onset patients with FEDN schizophrenia and 51 age- and sex-matched healthy controls. The Chinese version of the Positive and Negative Syndrome Scale (PANSS), Hamilton Anxiety Rating Scale, and Hamilton Depression Rating Scale were used to assess patients' psychiatric, anxiety, and depressive symptoms. The results showed that compared with healthy controls, the patients had a significantly higher prevalence of impaired fasting glucose and insulin resistance, as well as higher fasting plasma glucose, fasting plasma insulin, homeostasis model assessment of insulin resistance index (HOMA-IR) and triglycerides, but lower high-density lipo-protein cholesterol levels. Moreover, HOMA-IR was negatively associated with PANSS general psychopathology, while glucose was positively correlated with depressive symptoms among patients. In sum, adolescent-onset patients with FEDN schizophrenia are more likely to have abnormal glucose metabolism and dyslipidemia than their healthy counterparts. Moreover, abnormal glucose metabolism may be closely related to the psychopathological symptoms of schizophrenia in the early stage of the disease.
收录类别SCI
WOS关键词INSULIN-RESISTANCE ; DISTURBANCES ; METAANALYSIS ; HOMEOSTASIS ; TOLERANCE ; DOPAMINE ; SCALE ; MODEL
WOS研究方向Psychiatry
语种英语
出版者ELSEVIER
WOS记录号WOS:000677477200031
源URL[http://ir.psych.ac.cn/handle/311026/40086]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Zhou, Yongjie; Zhang, Xiangyang
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing, Peoples R China
2.Binzhou Med Univ, Yantai Affiliated Hosp, Clin Psychol, Yantai, Peoples R China
3.China Univ Geosci, Res Ctr Psychol & Hlth Sci, Wuhan, Peoples R China
4.Wuhan Polytech Univ, Sch Hlth Sci & Nursing, Wuhan, Peoples R China
5.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Med & Hlth Management, Wuhan, Peoples R China
6.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, 77 Zhenbi Rd, Shenzhen, Guangdong, Peoples R China
7.City Univ Hong Kong, Dept Social & Behav Sci, Kowloon Tong, Tat Chee Ave, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714		 Hu, Jinghan,Zhou, Yongjie,Wang, Ruoxi,et al. Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia[J]. ASIAN JOURNAL OF PSYCHIATRY,2021,62:5.
APA Hu, Jinghan.,Zhou, Yongjie.,Wang, Ruoxi.,Qi, Ling.,Zhou, Xin.,...&Zhang, Xiangyang.(2021).Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia.ASIAN JOURNAL OF PSYCHIATRY,62,5.
MLA Hu, Jinghan,et al."Abnormal glucose metabolism is associated with clinical symptoms of adolescent-onset patients with first-episode drug-naive schizophrenia".ASIAN JOURNAL OF PSYCHIATRY 62(2021):5.

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来源：心理研究所

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