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Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions

文献类型：期刊论文

作者Li, Gen3,4; Cao, Chengqi3,4; Fang, Ruojiao3,4; Liu, Ping2; Luo, Shu2; Liberzon, Israel1; Wang, Li3,4
刊名JOURNAL OF PSYCHIATRIC RESEARCH
出版日期2021-08-01
卷号140页码:30-34
关键词Anhedonia Traumatic stress Resting-state fMRI Ventral pallidum Default mode network
ISSN号0022-3956
DOI10.1016/j.jpsychires.2021.05.061
通讯作者Wang, Li(wangli1@psych.ac.cn)
英文摘要Anhedonia is common in individuals with traumatic experience. Anhedonia symptoms play an important role in posttraumatic psychopathology, and are related to various adverse outcomes. The current study is a preliminary neuroimaging study of the neural correlates of posttraumatic anhedonia symptoms. Resting-state fMRI data were acquired from 88 Chinese earthquake survivors. Whole brain analyses and exploratory ROI-to-ROI analyses were performed to examine the relationship between posttraumatic anhedonia symptoms and resting-state functional connectivity (rsFC) of reward-related subcortical nucleus including nucleus accumbens and ventral pallidum. The rsFC between left ventral pallidum and areas of bilateral posterior cingulate cortex (PCC) and precuneus cortex were found lower in the high posttraumatic anhedonia group, after controlling for sex, age and other posttraumatic stress symptoms. The rsFC between left ventral pallidum and PCC and the rsFC between left ventral pallidum and lateral parietal cortex were significantly lower in the high anhedonia group. Our findings suggest that decreased functional connectivity between the ventral pallidum and the brain default mode network (DMN) regions could be the neural correlates of posttraumatic anhedonia symptoms.
收录类别SCI
WOS关键词STRESS-DISORDER ; EPIDEMIOLOGIC SAMPLE ; REWARD ; PTSD ; PATTERNS ; DEPRESSION ; VETERANS ; ANATOMY ; ROLES ; WOMEN
资助项目National Natural Science Foundation of China[31471004] ; National Natural Science Foundation of China[31971020] ; Key Project of the National Social Science Foundation of China[20ZDA079] ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education[16JJD190006] ; Key Research Program of the Chinese Academy of Sciences[ZDRW-XH-2019-4]
WOS研究方向Psychiatry
语种英语
WOS记录号WOS:000677477100005
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Natural Science Foundation of China ; Key Project of the National Social Science Foundation of China ; Key Project of Research Base of Humanities and Social Sciences of Ministry of Education ; Key Research Program of the Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/40090]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Wang, Li
作者单位1.Univ Texas A&M Univ, Hlth Sci Ctr, Dept Psychiat, Bryan, TX USA
2.Peoples Hosp Deyang City, Deyang, Sichuan, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China
4.Inst Psychol, Lab Traumat Stress Studies, CAS Key Lab Mental Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Li, Gen,Cao, Chengqi,Fang, Ruojiao,et al. Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2021,140:30-34.
APA Li, Gen.,Cao, Chengqi.,Fang, Ruojiao.,Liu, Ping.,Luo, Shu.,...&Wang, Li.(2021).Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions.JOURNAL OF PSYCHIATRIC RESEARCH,140,30-34.
MLA Li, Gen,et al."Neural correlates of posttraumatic anhedonia symptoms: Decreased functional connectivity between ventral pallidum and default mode network regions".JOURNAL OF PSYCHIATRIC RESEARCH 140(2021):30-34.

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来源：心理研究所

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