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Disrupted intrinsic functional brain topology in patients with major depressive disorder

文献类型：期刊论文

作者Yang, Hong45; Chen, Xiao42,43,44; Chen, Zuo-Bing41; Li, Le40; Li, Xue-Ying38,39,44; Castellanos, Francisco Xavier36,37; Bai, Tong-Jian35; Bo, Qi-Jing34; Cao, Jun33; Chang, Zhi-Kai43,44
刊名MOLECULAR PSYCHIATRY
出版日期2021-08-12
页码9
ISSN号1359-4184
DOI10.1038/s41380-021-01247-2
通讯作者Yan, Chao-Gan(ycg.yan@gmail.com)
英文摘要Aberrant topological organization of whole-brain networks has been inconsistently reported in studies of patients with major depressive disorder (MDD), reflecting limited sample sizes. To address this issue, we utilized a big data sample of MDD patients from the REST-meta-MDD Project, including 821 MDD patients and 765 normal controls (NCs) from 16 sites. Using the Dosenbach 160 node atlas, we examined whole-brain functional networks and extracted topological features (e.g., global and local efficiency, nodal efficiency, and degree) using graph theory-based methods. Linear mixed-effect models were used for group comparisons to control for site variability; robustness of results was confirmed (e.g., multiple topological parameters, different node definitions, and several head motion control strategies were applied). We found decreased global and local efficiency in patients with MDD compared to NCs. At the nodal level, patients with MDD were characterized by decreased nodal degrees in the somatomotor network (SMN), dorsal attention network (DAN) and visual network (VN) and decreased nodal efficiency in the default mode network (DMN), SMN, DAN, and VN. These topological differences were mostly driven by recurrent MDD patients, rather than first-episode drug naive (FEDN) patients with MDD. In this highly powered multisite study, we observed disrupted topological architecture of functional brain networks in MDD, suggesting both locally and globally decreased efficiency in brain networks.
收录类别SCI
WOS关键词DEFAULT-MODE NETWORK ; CONNECTIVITY ; METAANALYSIS ; ABNORMALITIES ; INFORMATION ; REGIONS ; MATTER ; NAIVE
资助项目National Key R&D Program of China[2017YFC1309902] ; National Natural Science Foundation of China[81671774] ; National Natural Science Foundation of China[81820108018] ; National Natural Science Foundation of China[81630031] ; 13th Five-year Informatization Plan of Chinese Academy of Sciences[XXH13505] ; Key Research Program of the Chinese Academy of Sciences[ZDBS-SSW-JSC006] ; Beijing Nova Program of Science and Technology[Z191100001119104] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[Y9CX422005] ; China Postdoctoral Science Foundation[2019M660847] ; China National Postdoctoral Program for Innovative Talents[BX20200360] ; Key Project of Science and Technology Research Plan[2020-3-016] ; Key research and development program, Ministry of Science and Technology of People's Republic of China[2019YFC0121003] ; Basic Public Welfare Research Program of Zhejiang Province[LGF20H090013] ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain[NBSDC-DB-15]
WOS研究方向Biochemistry & Molecular Biology ; Neurosciences & Neurology ; Psychiatry
语种英语
出版者SPRINGERNATURE
WOS记录号WOS:000684516400005
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; 13th Five-year Informatization Plan of Chinese Academy of Sciences ; Key Research Program of the Chinese Academy of Sciences ; Beijing Nova Program of Science and Technology ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China National Postdoctoral Program for Innovative Talents ; Key Project of Science and Technology Research Plan ; Key research and development program, Ministry of Science and Technology of People's Republic of China ; Basic Public Welfare Research Program of Zhejiang Province ; Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center Chinese Data-sharing Warehouse for In-vivo Imaging Brain
源URL[http://ir.psych.ac.cn/handle/311026/39989]  
专题心理研究所_中国科学院行为科学重点实验室
通讯作者Yan, Chao-Gan
作者单位1.Chinese Acad Sci, Magnet Resonance Imaging Res Ctr, Inst Psychol, Beijing, Peoples R China
2.Beijing Normal Univ, IDGMcGovern Inst Brain Res, Beijing, Peoples R China
3.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China
4.Shanghai Jiao Tong Univ, Sch Med, Dept Psychiat, Shanghai, Peoples R China
5.Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Lab Psychol Hlth & Imaging, Shanghai, Peoples R China
6.Shanxi Med Univ, Hosp 1, Taiyuan, Shanxi, Peoples R China
7.Zhejiang Key Lab Res Assessment Cognit Impairme, Hangzhou, Zhejiang, Peoples R China
8.Hangzhou Normal Univ, Inst Psychol Sci, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
9.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China
10.Chongqing Key Lab Neurobiol, Chongqing, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Hong,Chen, Xiao,Chen, Zuo-Bing,et al. Disrupted intrinsic functional brain topology in patients with major depressive disorder[J]. MOLECULAR PSYCHIATRY,2021:9.
APA Yang, Hong.,Chen, Xiao.,Chen, Zuo-Bing.,Li, Le.,Li, Xue-Ying.,...&Yan, Chao-Gan.(2021).Disrupted intrinsic functional brain topology in patients with major depressive disorder.MOLECULAR PSYCHIATRY,9.
MLA Yang, Hong,et al."Disrupted intrinsic functional brain topology in patients with major depressive disorder".MOLECULAR PSYCHIATRY (2021):9.

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来源：心理研究所

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