An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue
文献类型:期刊论文
作者 | Tackley, George8,9; Kong, Yazhuo6,7,9; Minne, Rachel5; Messina, Silvia3; Winkler, Anderson2,9; Cavey, Ana3; Everett, Rosie3; DeLuca, Gabriele C.3; Weir, Andrew3; Craner, Matthew3 |
刊名 | NEUROIMAGE |
出版日期 | 2021-09-01 |
卷号 | 238页码:10 |
ISSN号 | 1053-8119 |
关键词 | Neuroinflammatory disorders Multiple Sclerosis Neuromyelitis optica Magnetic resonance spectroscopy Ultra-high field MRI |
DOI | 10.1016/j.neuroimage.2021.118225 |
产权排序 | 3 |
文献子类 | 实证研究 |
英文摘要 | Magnetic Resonance Spectroscopy (MRS) allows for the non-invasive quantification of neurochemicals and has the potential to differentiate between the pathologically distinct diseases, multiple sclerosis (MS) and AQP4Abpositive neuromyelitis optica spectrum disorder (AQP4Ab-NMOSD). In this study we characterised the metabolite profiles of brain lesions in 11 MS and 4 AQP4Ab-NMOSD patients using an optimised MRS methodology at ultrahigh field strength (7T) incorporating correction for T2 water relaxation differences between lesioned and normal tissue. MS metabolite results were in keeping with the existing literature: total N-acetylaspartate (NAA) was lower in lesions compared to normal appearing brain white matter (NAWM) with reciprocal findings for myo-Inositol. An unexpected subtlety revealed by our technique was that total NAA differences were likely driven by NAA-glutamate (NAAG), a ubiquitous CNS molecule with functions quite distinct from NAA though commonly quantified together with NAA in MRS studies as total NAA. Surprisingly, AQP4Ab-NMOSD showed no significant differences for total NAA, NAA, NAAG or myo-Inositol between lesion and NAWM sites, nor were there any differences between MS and AQP4Ab-NMOSD for a priori hypotheses. Post-hoc testing revealed a significant correlation between NAWM Ins:NAA and disability (as measured by EDSS) for disease groups combined, driven by the AP4Ab-NMOSD group. Utilising an optimised MRS methodology, our study highlights some under-explored subtleties in MRS profiles, such as the absence of myo-Inositol concentration differences in AQP4Ab-NMOSD brain lesions versus NAWM and the potential influence of NAAG differences between lesions and normal appearing white matter in MS. |
收录类别 | SCI |
WOS关键词 | MAGNETIC-RESONANCE-SPECTROSCOPY ; PROTON MR SPECTROSCOPY ; LONG T-2 WATER ; WHITE-MATTER ; DISEASE PROGRESSION ; DISABILITY ; DAMAGE ; ABNORMALITIES ; SPECTRA ; IMAGES |
资助项目 | MS Society[858/07] ; Guthy Jackson Charitable Foundation ; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre ; NIHR Oxford Health Biomedical Research Centre ; Wellcome Trust[203139/Z/16/Z] ; Economic and Social Research Council's (ESRC's) postdoctoral fellowship programme ; Wellcome Trust ; Royal Society[102584/Z/13/Z] |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS记录号 | WOS:000679331600009 |
资助机构 | MS Society ; Guthy Jackson Charitable Foundation ; National Institute for Health Research (NIHR) Oxford Biomedical Research Centre ; NIHR Oxford Health Biomedical Research Centre ; Wellcome Trust ; Economic and Social Research Council's (ESRC's) postdoctoral fellowship programme ; Wellcome Trust ; Royal Society |
源URL | [http://ir.psych.ac.cn/handle/311026/40046] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Tackley, George |
作者单位 | 1.Univ Oxford, MRC Brain Network Dynam Unit, Oxford OX1 3TH, England 2.NIMH, NIH, Bethesda, MD 20892 USA 3.Univ Oxford, Nuffield Dept Clin Neurosci, Div Clin Neurol, Oxford OX3 9DU, England 4.Purdue Univ, Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA 5.Purdue Univ, Sch Hlth Sci, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA 6.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 8.Cardiff Univ, Cardiff Univ Brain Res Imaging Ctr CUBRIC, Cardiff CF24 4HQ, S Glam, Wales 9.Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Nuffield Dept Clin Neurosci, FMRIB, Oxford OX3 9DU, England |
推荐引用方式 GB/T 7714 | Tackley, George,Kong, Yazhuo,Minne, Rachel,et al. An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue[J]. NEUROIMAGE,2021,238:10. |
APA | Tackley, George.,Kong, Yazhuo.,Minne, Rachel.,Messina, Silvia.,Winkler, Anderson.,...&Emir, Uzay.(2021).An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue.NEUROIMAGE,238,10. |
MLA | Tackley, George,et al."An In-vivo 1H-MRS short-echo time technique at 7T: Quantification of metabolites in chronic multiple sclerosis and neuromyelitis optica brain lesions and normal appearing brain tissue".NEUROIMAGE 238(2021):10. |
入库方式: OAI收割
来源:心理研究所
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