Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo
文献类型：期刊论文
| 作者 | Shen, JL; Tao, K; Gu, PL; Gui, C; Wang, D; Tan, ZY; Wang, LH; Wang, ZM; Qin, AJ; Tang, BZ |
| 刊名 | SCIENCE CHINA-CHEMISTRY
 |
| 出版日期 | 2020 |
| 卷号 | 63期号:3页码:393-397 |
| ISSN号 | 1674-7291 |
| 关键词 | CELL AIEGENS |
| DOI | 10.1007/s11426-019-9677-7 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Colorectal cancer (CRC) is still a major killer, mainly due to the lack of early detection biomarker with sensitivity/specificity. Conventional histopathology is the gold standard approach in practice, but there are still some issues (false diagnosis and long waiting period). Aggregation-induced emission (AIE) is a novel photophysical phenomenon which has been widely utilized for biological imaging in vivo, including malignant cells, showing remarkable imaging contrast and enhanced emission in high concentrated state. However, it is unclear if AIE dyes can identify malignant cells specifically in vivo. A great challenge for specific labeling of malignant cells is probably ascribed to the complex compositions in tumor tissues. Herein, an AIE dye-based mitochondria-targeted histological staining strategy was employed to localize cancer and the metastatic track in the fresh colorectal cancer. This novel approach holds great potential to revolutionize the clinical diagnosis and intervention for devastating malignancy. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32696]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Hong Kong Univ Sci & Technol, Div Life Sci, Inst Mol Funct Mat,Div Biomed Engn, HKUST Jockey Club Inst Adv Study,Dept Chem,State, Hong Kong, Peoples R China 2.South China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangzhou 510640, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 4.Shanghai Jiao Tong Univ, Tongren Hosp, Sch Med, Shanghai 200240, Peoples R China 5.Univ Sydney, Charles Perkins Ctr, Bosch Inst, Discipline Pathol, Sydney, NSW, Australia 6.Univ Sydney, Charles Perkins Ctr, Sch Med Sci, Sydney, NSW, Australia 7.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai Synchrotron Radiat Facil,CAS Key Lab Int, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, JL,Tao, K,Gu, PL,et al. Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo[J]. SCIENCE CHINA-CHEMISTRY,2020,63(3):393-397. |
| APA | Shen, JL.,Tao, K.,Gu, PL.,Gui, C.,Wang, D.,...&Bao, SS.(2020).Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo.SCIENCE CHINA-CHEMISTRY,63(3),393-397. |
| MLA | Shen, JL,et al."Aggregation-induced emission luminogen for specific identification of malignant tumour in vivo".SCIENCE CHINA-CHEMISTRY 63.3(2020):393-397. |
入库方式： OAI收割
来源：上海应用物理研究所
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