Blood exposure to graphene oxide may cause anaphylactic death in non-human primates
文献类型：期刊论文
| 作者 | Lin, YF; Zhang, Y; Li, J; Kong, HT; Yan, QL; Zhang, JC; Li, W; Ren, N; Cui, YZ; Zhang, T |
| 刊名 | NANO TODAY
 |
| 出版日期 | 2020 |
| 卷号 | 35页码:- |
| 关键词 | IN-VIVO CARBON NANOTUBES CHALLENGES DRUG NANOPARTICLES NANOSHEETS TOXICITY DELIVERY PROMISES BIOLOGY |
| ISSN号 | 1748-0132 |
| DOI | 10.1016/j.nantod.2020.100922 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Toxicological evaluation of graphene oxide (GO) has been actively pursued under the context of large-scale industrial production and the potential for clinical translation. Nevertheless, the safety of GO remains largely debated, especially due to the lack of toxicological profile in higher mammals. Here we show that blood exposure to GO under the maximum safe starting dose may cause accidental death of mammals, including non-human primates (1 in 5 Macaca fascicularis and 7 in 121 mice), while remains general amenable in others. Elevated levels of immunoglobulin E and severe lung injury were found in dead animals, suggesting the GO-induced acute anaphylactic reactions. Noticeably, we did not observe anaphylactic reactions and deaths for two other carbon nanomaterials, including single-walled carbon nanotubes and nanodiamonds. This difference might arise from the long in-vivo circulating time of two-dimensional GO materials. This study thus highlights the urgent need to evaluate the hypersensitivity risks of graphene and other nanomaterials. (C) 2020 The Author(s). Published by Elsevier Ltd. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32732]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Bioimaging Ctr, Shanghai Adv Res Inst, Zhangjiang Lab,Shanghai Synchrotron Radiat Facil, Shanghai 201210, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 3.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med,Shanghai Key Lab Nucle Acids Chem &, Shanghai 200240, Peoples R China 5.Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu 610041, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lin, YF,Zhang, Y,Li, J,et al. Blood exposure to graphene oxide may cause anaphylactic death in non-human primates[J]. NANO TODAY,2020,35:-. |
| APA | Lin, YF.,Zhang, Y.,Li, J.,Kong, HT.,Yan, QL.,...&Fan, CH.(2020).Blood exposure to graphene oxide may cause anaphylactic death in non-human primates.NANO TODAY,35,-. |
| MLA | Lin, YF,et al."Blood exposure to graphene oxide may cause anaphylactic death in non-human primates".NANO TODAY 35(2020):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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