DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery
文献类型：期刊论文
| 作者 | Ge, ZL; Guo, LJ; Wu, GQ; Li, J; Sun, YL; Hou, YQ; Shi, JY; Song, SP; Wang, LH; Fan, CH |
| 刊名 | SMALL
 |
| 出版日期 | 2020 |
| 卷号 | 16期号:16页码:- |
| 关键词 | TRASTUZUMAB EMTANSINE BRENTUXIMAB VEDOTIN CANCER-THERAPY ANTIBODY NANOSTRUCTURES NANOROBOT TRANSPORT EFFICACY IMPROVES SYSTEM |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201904857 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Effective drug delivery systems that can systematically and selectively transport payloads to disease cells remain a challenge. Here, a targeting ligand-modified DNA origami nanostructure (DON) as an antibody-drug conjugate (ADC)-like carrier for targeted prostate cancer therapy is reported. Specifically, DON of six helical bundles is modified with a ligand 2-[3-(1,3-dicarboxy propyl)-ureido] pentanedioic acid (DUPA) against prostate-specific membrane antigen (PSMA), to serve as the antibody for drug conjugation in ADC. Doxorubicin (Dox) is then loaded to DON through intercalation to dsDNA. This platform features in spatially controllable organization of targeting ligands and high drug loading capacity. With this nanocomposite, selective delivery of Dox to the PSMA+ cancer cell line LNCaP is readily achieved. The consequent therapeutic efficacy is critically dependent on the numbers of targeting ligand assembled on DON. This target-specific and biocompatible drug delivery platform with high maximum tolerated doses shows immense potential for developing novel nanomedicine. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32810]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Inst Mol Med, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China 2.Peking Univ, Beijing Natl Lab Mol Sci, Ctr Soft Matter Sci & Engn, Key Lab Polymer Chem & Phys,Minist Educ,Coll Chem, Beijing 100871, Peoples R China 3.Chinese Acad Sci, Bioimaging Ctr, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 4.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Renji Hosp, Sch Med, Shanghai 200240, Peoples R China 5.Chinese Acad Sci, Div Phys Biol, Shanghai Synchrotron Radiat Facil, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, ZL,Guo, LJ,Wu, GQ,et al. DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery[J]. SMALL,2020,16(16):-. |
| APA | Ge, ZL.,Guo, LJ.,Wu, GQ.,Li, J.,Sun, YL.,...&Li, Q.(2020).DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery.SMALL,16(16),-. |
| MLA | Ge, ZL,et al."DNA Origami-Enabled Engineering of Ligand-Drug Conjugates for Targeted Drug Delivery".SMALL 16.16(2020):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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