Evaluation of plan quality and robustness of IMPT and helical IMRT for cervical cancer
文献类型：期刊论文
| 作者 | Shang, HJ; Pu, YH; Wang, W; Dai, ZT; Jin, F |
| 刊名 | RADIATION ONCOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 15期号:1页码:- |
| 关键词 | MODULATED PROTON THERAPY TREATMENT UNCERTAINTIES PELVIC RADIOTHERAPY RADIATION-THERAPY OPTIMIZATION VOLUME SENSITIVITY REDUCTION RANGE HEAD |
| ISSN号 | 1748-717X |
| DOI | 10.1186/s13014-020-1483-x |
| 文献子类 | 期刊论文 |
| 英文摘要 | Background Both plan quality and robustness were investigated through comparing some dosimetric metrics between intensity modulated proton therapy (IMPT) and helical tomotherapy based intensity modulated radiotherapy (IMRT) for cervical cancer. Methods Both a spot-scanning robust (SRO) IMPT plan and a helical tomotherapy robust (TRO) IMRT plan were generated for each of 18 patients. In order to evaluate the quality of nominal plans without dose perturbations, planning scores (PS) on clinical target volume (CTV) and five organs at risk (OARs) based on clinical experience, and normal tissue complication probabilities (NTCP) of rectum and sigmoid were calculated based on Lyman-Kutcher-Burman (LKB) model. Dose volume histogram bands width (DVHBW) were calculated in 28 perturbed scenarios to evaluate plan robustness. Results Compared with TRO, the average scores of SRO nominal plans were higher in target metrics [V-46.8Gy, V-50Gy, Conformity and Homogeneity](16.5 vs. 15.1), and in OARs metrics (60.9 vs. 53.3), including bladder [V-35,V-45, D-mean,D-2cc], rectum [V-40,V-45,D-2cc,D-max], bowel [V-35,V-40,V-45, D-max], sigmoid [V-40,D-max] and femoral heads [V-30,D-max]. Meanwhile, NTCP calculation showed that the toxicities of rectum and sigmoid in SRO were lower than those in TRO (rectum: 2.8% vs. 4.8%, p < 0.05; sigmoid: 5.2% vs. 5.7%, p < 0.05). DVHBW in target coverage for the SRO plan was smaller than that for the TRO plan (0.6% vs. 2.1%), which means that the SRO plan generated a more robust plan in target. Conclusion Better CTV coverage and OAR Sparing were obtained in SRO nominal plan. Based on NTCP calculation, SRO was expected to allow a small reduction in rectal toxicity. Furthermore, SRO generated a more robust plan in CTV target coverage. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32863]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Med, Xinhua Hosp, Dept Radiat Oncol, Shanghai, Peoples R China 2.Chongqing Canc Hosp, 181 Hanyu Rd, Chongqing 400030, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.RaySearch China, Shanghai 200120, Peoples R China 6.Chongqing Canc Inst, 181 Hanyu Rd, Chongqing 400030, Peoples R China 7.Wuhan Univ, Sch Phys & Technol, Wuhan 430072, Peoples R China 8.Chongqing Univ Canc Hosp, Dept Radiat Oncol, 181 Hanyu Rd, Chongqing 400030, Peoples R China 9.Chinese Acad Med Sci & Peking Union Med Coll, Shenzhen Hosp, Shenzhen, Peoples R China 10.Chinese Acad Med Sci & Peking Union Med Coll, Natl Canc Ctr, Natl Clin Res Ctr Canc, Canc Hosp, Shenzhen, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shang, HJ,Pu, YH,Wang, W,et al. Evaluation of plan quality and robustness of IMPT and helical IMRT for cervical cancer[J]. RADIATION ONCOLOGY,2020,15(1):-. |
| APA | Shang, HJ,Pu, YH,Wang, W,Dai, ZT,&Jin, F.(2020).Evaluation of plan quality and robustness of IMPT and helical IMRT for cervical cancer.RADIATION ONCOLOGY,15(1),-. |
| MLA | Shang, HJ,et al."Evaluation of plan quality and robustness of IMPT and helical IMRT for cervical cancer".RADIATION ONCOLOGY 15.1(2020):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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