Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer
文献类型：期刊论文
| 作者 | Shang, Haijiao2,3,4; Pu, Yuehu2,3; Chen, Zhiling5; Wang, Xuetao6; Yuan, Cuiyun7; Jin, Xiance1; Liu, Chenbin7 |
| 刊名 | ACS Sensors
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| 出版日期 | 2020 |
| 关键词 | Proton beam therapy Bandwidth Biological organs Degrees of freedom (mechanics) Diseases Energy transfer Graphic methods Heart Optimization Proton beams Quality control Dose volume histograms Intensity modulated proton therapies Internal target volume Linear energy transfer Potential benefits Relative biological effectiveness Robust optimization Treatment planning systems |
| ISSN号 | 2379-3694 |
| DOI | 10.1021/acssensors.0c01879 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The increase of proton beam number might provide higher degrees of freedom in the optimization of intensity-modulated proton therapy planning. In this study, we aimed to quantitatively explore the potential benefits of the increased beam number, including dose volume histogram (DVH), linear energy transfer volume histogram, and DVH bandwidth metrics. Twelve patients with lung cancer are retrospectively selected. Four plans were created based on internal target volume (ITV) robust optimization for each patient using the RayStation treatment planning system. Four plans were generated using different numbers (three, five, seven, and nine) of evenly separated coplanar beams. The three-beam plan was considered as the reference plan. Biologically equivalent doses were calculated using both constant relative biological effectiveness (RBE) and variable RBE models, respectively. To evaluate plan quality, DVH metrics in the target [ITV: D2%, CI, HI] and organs-at-risk [Lung: V5Gy[RBE], V20Gy[RBE], V30Gy[RBE]; Heart D2%; Spinal cord D2%] were calculated using both RBE models. To evaluate LET distributions, LET volume histogram metrics [ITV LETmean and LET2%; Lung LETmean and LET2%; Heart LET2%; Spinal cord LET2%] were quantified. To evaluate plan robustness, the metrics using DVH bandwidth [ITV: D2%, D99%; Lung: V5Gy[RBE], V20Gy[RBE], V30Gy[RBE]; Heart D2%; Spinal cord D2%] were also reported. For plan quality, the increase of proton beam number resulted in fewer target hot spots, improved target dose conformity, improved target dose homogeneity, lower median-dose lung volume, and fewer hot spots in spinal cord. As to LET distributions, target mean LET increased significantly as the beam number increased to seven or more. Lung LET hot spots were significantly reduced with the increase of proton beams. With respect to plan robustness, the robustness of target dose coverage, target hot spots, and low-dose lung volume were improved, while the robustness of heart hot spots became worse as the beam number increased to nine. The robustness of cord hot spots became worse using five and seven beams compared to that using three beams. As the proton beam number increased, plan quality and LET distributions were comparable or significantly improved. The robustness of target dose coverage, target dose hot spots, and low-dose lung volume were significantly improved. © |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32921]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Department of Radiation and Medical Oncology, 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou; 32500, China 2.Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai; 201800, China; 3.University of Chinese Academy of Sciences, Beijing; 100049, China; 4.RaySearch China, Shanghai; 200120, China; 5.Shanghai Advanced Research Institute, Chinese Academy Sciences, Shanghai; 201210, China; 6.Department of Radiation Oncology, West China Hospital, Sichuan University, Chengdu; 610041, China; 7.Department of Radiation Oncology, Natl. Cancer Ctr./National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen; 518116, China; |
| 推荐引用方式 GB/T 7714 | Shang, Haijiao,Pu, Yuehu,Chen, Zhiling,et al. Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer[J]. ACS Sensors,2020. |
| APA | Shang, Haijiao.,Pu, Yuehu.,Chen, Zhiling.,Wang, Xuetao.,Yuan, Cuiyun.,...&Liu, Chenbin.(2020).Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer.ACS Sensors. |
| MLA | Shang, Haijiao,et al."Impact of Multiple Beams on Plan Quality, Linear Energy Transfer Distribution, and Plan Robustness of Intensity Modulated Proton Therapy for Lung Cancer".ACS Sensors (2020). |
入库方式： OAI收割
来源：上海应用物理研究所
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