Implementing digital computing with DNA-based switching circuits
文献类型：期刊论文
| 作者 | Wang, F; Lv, H; Li, Q; Li, J; Zhang, XL; Shi, JY; Wang, LH; Fan, CH |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2020 |
| 卷号 | 11期号:1页码:- |
| 关键词 | STRAND-DISPLACEMENT COMPUTATION GATE |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-019-13980-y |
| 文献子类 | 期刊论文 |
| 英文摘要 | DNA strand displacement reactions (SDRs) provide a set of intelligent toolboxes for developing molecular computation. Whereas SDR-based logic gate circuits have achieved a high level of complexity, the scale-up for practical achievable computational tasks remains a hurdle. Switching circuits that were originally proposed by Shannon in 1938 and nowadays widely used in telecommunication represent an alternative and efficient means to realize fast-speed and high-bandwidth communication. Here we develop SDR-based DNA switching circuits (DSCs) for implementing digital computing. Using a routing strategy on a programmable DNA switch canvas, we show that arbitrary Boolean functions can be represented by DSCs and implemented with molecular switches with high computing speed. We further demonstrate the implementation of full-adder and square-rooting functions using DSCs, which only uses down to 1/4 DNA strands as compared with a dual-rail logic expression-based design. We expect that DSCs provide a design paradigm for digital computation with biomolecules. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32922]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil, Shanghai 201210, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Chem & Chem Engn, Sch Med,Inst Mol Med, Shanghai 201240, Peoples R China 3.Southern Med Univ, Affiliated Fengxian Hosp, Joint Res Ctr Precis Med Shanghai Jiao Tong Univ, Shanghai 201499, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol, Shanghai 201800, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.East China Normal Univ, Sch Chem & Mol Engn, Shanghai Key Lab Green Chem & Chem Proc, 500 Dongchuan Rd, Shanghai 200241, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, F,Lv, H,Li, Q,et al. Implementing digital computing with DNA-based switching circuits[J]. NATURE COMMUNICATIONS,2020,11(1):-. |
| APA | Wang, F.,Lv, H.,Li, Q.,Li, J.,Zhang, XL.,...&Fan, CH.(2020).Implementing digital computing with DNA-based switching circuits.NATURE COMMUNICATIONS,11(1),-. |
| MLA | Wang, F,et al."Implementing digital computing with DNA-based switching circuits".NATURE COMMUNICATIONS 11.1(2020):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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