Low-molecular-weight chitosan relieves enterotoxigenic Escherichia coli-induced growth retardation in weaned pigs
文献类型：期刊论文
| 作者 | Zhang, J; Wan, J; Wu, GZ; Chen, DW; Yu, B; Huang, ZQ; Mao, XB; Zheng, P; Yu, J; He, J |
| 刊名 | INTERNATIONAL IMMUNOPHARMACOLOGY
 |
| 出版日期 | 2020 |
| 卷号 | 78页码:- |
| 关键词 | BARRIER FUNCTION PROINFLAMMATORY CYTOKINE LACTOBACILLUS-PLANTARUM INTESTINAL MORPHOLOGY PERFORMANCE RESISTANCE DIARRHEA OLIGOSACCHARIDE SUPPLEMENTATION COLIBACILLOSIS |
| ISSN号 | 1567-5769 |
| DOI | 10.1016/j.intimp.2019.105798 |
| 文献子类 | 期刊论文 |
| 英文摘要 | The objective of the present study was to evaluate the effects of low-molecular-weight chitosan (LMWC) on the growth performance, immune responses and intestinal health of weaned pigs challenged by enterotoxigenic Escherichia colt (ETEC). A total of 32 weaned pigs were randomly allocated to four treatments: non-challenged (fed with basal diet), ETEC-challenged (fed with basal diet) and ETEC-challenged plus 50 or 100 mg/kg LMWC supplementation, respectively. After 11 days feeding, the non-challenged pigs were infused with sterilised Luria-Bertani culture, while the remaining pigs were infused with 2.6 x 10(11) colony-forming units of ETEC. At 3 days post-challenge, all pigs were administered D-xylose at 0.1 g/kg body weight. One hour later, blood samples were obtained, and the pigs then euthanised to collect intestinal samples. Data showed that only 100 mg/kg LMWC supplementation attenuated (P < 0.05) the average daily gain reduction caused by ETEC. Furthermore, besides the decreased (P < 0.05) serum tumour necrosis factor-alpha and immunoglobulin (Ig) G concentrations detected in ETEC-challenged pigs supplemented with LMWC at 50 or 100 mg/kg, the higher dose (100 mg/kg) also decreased (P < 0.05) the serum IgM concentration and increased (P < 0.05) the villus height and villus height-to-crypt depth ratio in both the jejunum and ileum, and the sucrase activity in the ileal mucosa. Moreover, LMWC supplementation (50 or 100 mg/kg) in ETEC-challenged pigs elevated (P < 0.05) the mRNA levels of jejunal mucosal peptide transporter 1 and ileal mucosal peptide transporter 1, divalent metal transporter 1 and zinc transporter 1, and decreased (P < 0.05) the ileal and caecal E. coli abundances, while 100 mg/kg LMWC additionally elevated (P < 0.05) the ileal Bacillus abundance, and caecal and colonic Bifidobacteriwn abundances. These results suggest that LMWC helps alleviate ETEC-induced growth retardation in weaned pigs, which could be associated with the inhibition of the immune responses and improved intestinal health. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/32984]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Sichuan Agr Univ, Inst Anim Nutr, Chengdu 611130, Sichuan, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, J,Wan, J,Wu, GZ,et al. Low-molecular-weight chitosan relieves enterotoxigenic Escherichia coli-induced growth retardation in weaned pigs[J]. INTERNATIONAL IMMUNOPHARMACOLOGY,2020,78:-. |
| APA | Zhang, J.,Wan, J.,Wu, GZ.,Chen, DW.,Yu, B.,...&He, J.(2020).Low-molecular-weight chitosan relieves enterotoxigenic Escherichia coli-induced growth retardation in weaned pigs.INTERNATIONAL IMMUNOPHARMACOLOGY,78,-. |
| MLA | Zhang, J,et al."Low-molecular-weight chitosan relieves enterotoxigenic Escherichia coli-induced growth retardation in weaned pigs".INTERNATIONAL IMMUNOPHARMACOLOGY 78(2020):-. |
入库方式： OAI收割
来源：上海应用物理研究所
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