One-Dimensional Synergistic Core-Shell Nanozymes with Superior Peroxidase-like Activity for Ultrasensitive Colorimetric Detection of Blood Cholesterol
文献类型：期刊论文
| 作者 | Peng, Hongzhen1,2; Zhang, Jiaxing6; Zeng, Caixia6; Zhou, Chaoqun3,4; Li, Qingnuan5; Lu, Na6; Wang, Lihua1 |
| 刊名 | ACS Applied Bio Materials
 |
| 出版日期 | 2020 |
| 卷号 | 3期号:8页码:5111-5119 |
| ISSN号 | 2576-6422 |
| 关键词 | Cholesterol Biosensors Color Colorimetry Diagnosis Green manufacturing Iron oxides Magnetite Nanocatalysts Nanostructures Shells (structures) Cholesterol determination Colorimetric biosensors Colorimetric detection Hierarchically porous Hybrid nanostructures Optimized conditions Peroxidase like activities Point of care testing |
| DOI | 10.1021/acsabm.0c00588 |
| 文献子类 | 期刊论文 |
| 英文摘要 | In this paper, a simple and green strategy was proposed to fabricate one-dimensional core-shell Fe3O4@C/Ni nanocomposites. The rationally designed hybrid nanostructures notably exhibited an extremely excellent peroxidase-mimicking property, arising from the synergetic effects of Fe3O4, carbon, and Ni nanoparticles, along with the hollow and hierarchically porous nanostructures. Based upon the outstanding peroxidase-like activity and cholesterol oxidase cascade reaction, a label-free, ultrasensitive, and highly selective colorimetric assay for cholesterol determination has been developed. Under the optimized conditions, the colorimetric biosensor demonstrated a linear response to cholesterol ranging from 5 to 200 μM, with a relatively low detection limit of 0.17 μM. More importantly, cholesterol determination as low as 5 μM could be directly distinguished with the naked eye. In addition, we successfully determined the total cholesterol content in human serum samples with satisfactory accuracy and good precision. The Fe3O4@C/Ni nanocatalyst-based colorimetric biosensor provides great potential in point-of-care testing in disease diagnosis. © 2020 American Chemical Society. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/33051]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Synchrotron Radiation Facility, Zhangjiang Laboratory, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai; 201210, China; 2.Division of Physical Biology and Bioimaging Center, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai; 201800, China; 3.Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai; 200241, China 4.Pennsylvania State University, 128 Stamford Heights, State College; PA; 16803, United States; 5.Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai; 201800, China; 6.School of Materials Engineering, Shanghai University of Engineering Science, Shanghai; 201620, China; |
| 推荐引用方式 GB/T 7714 | Peng, Hongzhen,Zhang, Jiaxing,Zeng, Caixia,et al. One-Dimensional Synergistic Core-Shell Nanozymes with Superior Peroxidase-like Activity for Ultrasensitive Colorimetric Detection of Blood Cholesterol[J]. ACS Applied Bio Materials,2020,3(8):5111-5119. |
| APA | Peng, Hongzhen.,Zhang, Jiaxing.,Zeng, Caixia.,Zhou, Chaoqun.,Li, Qingnuan.,...&Wang, Lihua.(2020).One-Dimensional Synergistic Core-Shell Nanozymes with Superior Peroxidase-like Activity for Ultrasensitive Colorimetric Detection of Blood Cholesterol.ACS Applied Bio Materials,3(8),5111-5119. |
| MLA | Peng, Hongzhen,et al."One-Dimensional Synergistic Core-Shell Nanozymes with Superior Peroxidase-like Activity for Ultrasensitive Colorimetric Detection of Blood Cholesterol".ACS Applied Bio Materials 3.8(2020):5111-5119. |
入库方式： OAI收割
来源：上海应用物理研究所
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