Programming Cell-Cell Communications with Engineered Cell Origami Clusters
文献类型：期刊论文
| 作者 | Ge, ZL; Liu, JB; Guo, LJ; Yao, GB; Li, Q; Wang, LH; Li, J; Fan, CH |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2020 |
| 卷号 | 142期号:19页码:8800-8808 |
| ISSN号 | 0002-7863 |
| 关键词 | GAP-JUNCTION DNA ROUTE DEATH |
| DOI | 10.1021/jacs.0c01580 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Cells existing in the form of clusters often exhibit distinct physiological functions from their monodispersed forms, which have a close association with tissue and organ development, immunoresponses, and cancer metastasis. Nevertheless, the ability to construct artificial cell clusters as in vitro models for probing and manipulating intercellular communications remains limited. Here we design DNA origami nanostructure (DON)-based biomimetic membrane channels to organize cell origami clusters (COCs) with controlled geometric configuration and cell-cell communications. We demonstrate that programmable patterning of homotypic and heterotypic COCs with different configurations can result in three distinct types of intercellular communications: gap junctions, tunneling nanotubes, and immune/tumor cell interactions. In particular, the organization of T cells and cancer cells with a prescribed ratio and geometry can program in vitro immunoresponses, providing a new route to understanding and engineering cancer immunotherapy. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/33090]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Zhangjiang Lab, Shanghai Adv Res Inst, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 2.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Inst Mol Med,Renji Hosp,Sch Med, Shanghai 200024, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, CAS Key Lab Interfacial Phys & Technol, Div Phys Biol, Shanghai 201800, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ge, ZL,Liu, JB,Guo, LJ,et al. Programming Cell-Cell Communications with Engineered Cell Origami Clusters[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2020,142(19):8800-8808. |
| APA | Ge, ZL.,Liu, JB.,Guo, LJ.,Yao, GB.,Li, Q.,...&Fan, CH.(2020).Programming Cell-Cell Communications with Engineered Cell Origami Clusters.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,142(19),8800-8808. |
| MLA | Ge, ZL,et al."Programming Cell-Cell Communications with Engineered Cell Origami Clusters".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 142.19(2020):8800-8808. |
入库方式： OAI收割
来源：上海应用物理研究所
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