Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone
文献类型：期刊论文
| 作者 | Dai, Y; Guo, H; Chu, LY; He, ZH; Wang, MQ; Zhang, SH; Shang, XF |
| 刊名 | JOURNAL OF ORTHOPAEDIC TRANSLATION
 |
| 出版日期 | 2020 |
| 卷号 | 24页码:198-208 |
| ISSN号 | 2214-031X |
| 关键词 | STRUCTURAL ORTHOPEDIC IMPLANTS SILICON-NITRIDE OSSEOINTEGRATION PROLIFERATION DIFFERENTIATION MICROSTRUCTURE COMPOSITE SCAFFOLD CELLS |
| DOI | 10.1016/j.jot.2019.10.011 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Objective: To enhance the bioactivity of polyetheretherketone (PEEK) while maintain its mechanical strengths. Methods: Suspension coating and melt bonding. Results: Silicon nitride (Si3N4, SN) coating lead to higher surface roughness, hydrophilicity and protein absorption; SN coating could slowly release Si ion into simulated body fluid (SBF), which caused weak alkaline of micro-environment owing to the slight dissolution of SN; SN coating resulted in the improvements of adhesion, proliferation, differentiation and gene expressions of MC3T3-E1 cells in vitro; SN coating of PEEK with bioactive SN coating (CSNPK) obviously promoted bone regeneration and osseointegration in vivo. Conclusions: CSNPK with SN coating as bone implant might be a promising candidate for orthopedic implants. The Translational Potential of this Article: The silicon nitride-coated polyetheretherketone (CSNPK) prepared in this article could induce MC3T3-E1 cells adhesion, proliferation and differentiation in vitro; it could also induce bone regeneration in bone defect in vivo, which indicate its good cytocompatibility and biocompatibility. If the raw materials are medical grade, and preparation process as well as production process of this article are further improved, it will have great translational potential. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/33093]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med,Shanghai Key Lab Orthopaed Implants, Shanghai 200011, Peoples R China 2.Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai Synchrotron Radiat Facil, 239 Zhangheng Rd, Shanghai 201204, Peoples R China 3.Shandong Univ, Jinan 250012, Shandong, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Appl Phys, 2019 Jialuo Rd, Shanghai 201800, Peoples R China 5.Univ Sci & Technol China, Affiliated Hosp USTC 1, Dept Orthopaed Surg, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Y,Guo, H,Chu, LY,et al. Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2020,24:198-208. |
| APA | Dai, Y.,Guo, H.,Chu, LY.,He, ZH.,Wang, MQ.,...&Shang, XF.(2020).Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone.JOURNAL OF ORTHOPAEDIC TRANSLATION,24,198-208. |
| MLA | Dai, Y,et al."Promoting osteoblasts responses in vitro and improving osteointegration in vivo through bioactive coating of nanosilicon nitride on polyetheretherketone".JOURNAL OF ORTHOPAEDIC TRANSLATION 24(2020):198-208. |
入库方式： OAI收割
来源：上海应用物理研究所
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