Radiolabeling and biological evaluation of I-125-Necitumumab for EGFR-targeted SPECT imaging
文献类型：期刊论文
| 作者 | Lu, XM; Li, X; Peng, Y; Wang, T; Li, DN; Jia, LN; Zhang, L |
| 刊名 | JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
 |
| 出版日期 | 2020 |
| 卷号 | 323期号:1页码:83-89 |
| 关键词 | NECITUMUMAB CANCER EXPRESSION CETUXIMAB ANTIBODY IMPACT TUMOR |
| ISSN号 | 0236-5731 |
| DOI | 10.1007/s10967-019-06933-8 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Radiolabeled epidermal growth factor receptor (EGFR) targeted antibody could be used for imaging EGFR expressing cancer. In this study, the SPECT probe I-125-Necitumumab were synthesized and evaluated for SPECT imaging of non-small cell lung cancer (NSCLC). In vivo biodistribution study indicated that I-125-Necitumumab was cleared rapidly in most organs and tissues. Though the tumor expressed a relatively high level of EGFR, however SPECT images showed no obvious uptake in the tumors. Therefore, we considered that I-125-Necitumumab was not suitable for EGFR-targeted NSCLC SPECT imaging. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/33100]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys SINAP, Shanghai 201800, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Changhai Hosp, Dept Nucl Med, Shanghai 200433, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, XM,Li, X,Peng, Y,et al. Radiolabeling and biological evaluation of I-125-Necitumumab for EGFR-targeted SPECT imaging[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2020,323(1):83-89. |
| APA | Lu, XM.,Li, X.,Peng, Y.,Wang, T.,Li, DN.,...&Zhang, L.(2020).Radiolabeling and biological evaluation of I-125-Necitumumab for EGFR-targeted SPECT imaging.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,323(1),83-89. |
| MLA | Lu, XM,et al."Radiolabeling and biological evaluation of I-125-Necitumumab for EGFR-targeted SPECT imaging".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 323.1(2020):83-89. |
入库方式： OAI收割
来源：上海应用物理研究所
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