Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes
文献类型：期刊论文
| 作者 | Shen, ZW; Guo, Z; Tan, TY; Hu, J; Zhang, Y |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2020 |
| 卷号 | 6期号:7页码:3957-3966 |
| 关键词 | OXIDATIVE STRESS DAMAGE STEM-CELLS SUPPRESSION THERAPY ALPHA |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.0c00340 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Myocardial ischemia-reperfusion produces a large amount of reactive oxygen species (ROS), which damage the myocardial tissue. Therefore, localized scavenging of ROS from the myocardial tissue would reduce its damage and avoid metabolic abnormalities caused by systemic ROS. In this study, a free radical scavenging and biodegradable supramolecular peptide (ECAFF, named as ECF-5) hydrogel was designed as a culture scaffold for cardiomyocytes. The peptide hydrogel significantly preserved the migration and proliferation of cardiomyocytes and reduced their damage from oxidative stress. In addition, the hydrogel degraded during cell growth, which implies that it may avoid thrombosis of the capillaries in practical use and provide the opportunity for the cells to attach to each other and form a functional tissue. The hydrogel can be used as a 3D culture scaffold for cardiomyocyte culture and allow cardiomyocytes to grow into tissue-like cell spheres. The excellent nature of the ECF-5 hydrogel enables it to have broad applications in the biomedical field in the future. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/33105]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Key Lab Interfacial Phys & Technol, Shanghai 201800, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Zhangjiang Lab, Shanghai Adv Res Inst, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shen, ZW,Guo, Z,Tan, TY,et al. Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(7):3957-3966. |
| APA | Shen, ZW,Guo, Z,Tan, TY,Hu, J,&Zhang, Y.(2020).Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(7),3957-3966. |
| MLA | Shen, ZW,et al."Reactive Oxygen Species Scavenging and Biodegradable Peptide Hydrogel as 3D Culture Scaffold for Cardiomyocytes".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.7(2020):3957-3966. |
入库方式： OAI收割
来源：上海应用物理研究所
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