Unraveling Cell-Type-Specific Targeted Delivery of Membrane-Camouflaged Nanoparticles with Plasmonic Imaging
文献类型：期刊论文
| 作者 | Xie, XD; Hu, XJ; Li, Q; Yin, M; Song, HY; Hu, J; Wang, LH; Fan, CH; Chen, N |
| 刊名 | NANO LETTERS
 |
| 出版日期 | 2020 |
| 卷号 | 20期号:7页码:5228-5235 |
| 关键词 | BIOMIMETIC NANOPARTICLES GOLD NANOPARTICLES LIPID RAFTS INTEGRIN ALPHA-V-BETA-3 PEPTIDES SELF |
| ISSN号 | 1530-6984 |
| DOI | 10.1021/acs.nanolett.0c01503 |
| 文献子类 | 期刊论文 |
| 英文摘要 | Cell-membrane-camouflaged nanoparticles (CMCNPs) have been increasingly exploited to develop various therapeutic tools due to their high biocompatibility and cell-type-specific tumor-targeting properties. However, the molecular mechanism of CMCNPs for homotypic targeting remains elusive. Here, we develop a plasmonic imaging method by coating gold nanoparticles (AuNPs) with cancer cell membranes and perform plasmonic imaging of the interactions between CMC-NPs and living cells at the single-cell level. Quantitative analysis of CMC-NPs in a different clustering status reveals that the presence of cell membranes on CMC-NPs results in a 7-fold increase in homotypic cell delivery and nearly 2 orders of magnitude acceleration of the intracellular agglomeration process. Significantly, we identify that integrin alpha(v)beta(3), a cell surface receptor abundantly expressed in tumor cells, is critical for the selective cell recognition of CMC-NPs. We thus establish a single-cell plasmonic imaging platform for probing NP-cell interactions, which sheds new light on the therapeutic applications of CMC-NPs. |
| 语种 | 英语 |
| 源URL | [http://ir.sinap.ac.cn/handle/331007/33258]  |
| 专题 | 上海应用物理研究所_中科院上海应用物理研究所2011-2017年 |
| 作者单位 | 1.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Sch Med, Frontiers Sci Ctr Transformat Mol, Shanghai 200240, Peoples R China 2.Shanghai Jiao Tong Univ, Inst Mol Med, Shanghai Key Lab Nucle Acids Chem & Nanomed, Shanghai 200240, Peoples R China 3.Shanghai Normal Univ, Coll Chem & Mat Sci, Shanghai 200234, Peoples R China 4.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol,CAS Key Lab Interfacial Phys & Tech, Shanghai 201800, Peoples R China 5.Shanghai Jiao Tong Univ, State Key Lab Oncogenes & Related Genes, Ctr Single Cell Omics, Sch Publ Hlth,Sch Med, Shanghai 200025, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Frontiers Sci Ctr Transformat Mol, Shanghai 200240, Peoples R China 7.Shanghai Jiao Tong Univ, Shanghai Key Lab Nucle Acids Chem & Nanomed, Inst Mol Med, Renji Hosp,Sch Med, Shanghai 200240, Peoples R China 8.Chinese Acad Sci, Zhangjiang Lab, Shanghai Adv Res Inst, Bioimaging Ctr Shanghai Synchrotron Radiat Facil, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, XD,Hu, XJ,Li, Q,et al. Unraveling Cell-Type-Specific Targeted Delivery of Membrane-Camouflaged Nanoparticles with Plasmonic Imaging[J]. NANO LETTERS,2020,20(7):5228-5235. |
| APA | Xie, XD.,Hu, XJ.,Li, Q.,Yin, M.,Song, HY.,...&Chen, N.(2020).Unraveling Cell-Type-Specific Targeted Delivery of Membrane-Camouflaged Nanoparticles with Plasmonic Imaging.NANO LETTERS,20(7),5228-5235. |
| MLA | Xie, XD,et al."Unraveling Cell-Type-Specific Targeted Delivery of Membrane-Camouflaged Nanoparticles with Plasmonic Imaging".NANO LETTERS 20.7(2020):5228-5235. |
入库方式： OAI收割
来源：上海应用物理研究所
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