Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat
文献类型：期刊论文
| 作者 | Chen, Yi; Hou, Guanmei; Jing, Meidong; Teng, Huajing; Liu, Quansheng; Yang, Xingen; Wang, Yong; Qu, Jiapeng ; Shi, Chengmin; Lu, Liang
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| 刊名 | MOLECULAR ECOLOGY
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| 出版日期 | 2021 |
| 关键词 | colonization pattern hypoxia adaptation invasion mechanism northward invasion Rattus tanezumi reference genome |
| 英文摘要 | The Asian house rat (AHR), Rattus tanezumi, has recently invaded the northern half of China. The AHR is a highly adaptive rat species that has also successfully conquered the Qinghai-Tibet Plateau (QTP) and replaced the brown rat (BR), R. norvegicus, at the edge of the QTP. Here, we assembled a draft genome of the AHR and explored the mechanisms of its northward invasion and the genetic basis underlying plateau adaptation in this species. Population genomic analyses revealed that the northwardly invasive AHRs consisted of two independent and genetically distinct populations which might result from multiple independent primary invasion events. One invasive population exhibited reduced genetic diversity and distinct population structure compared with its source population, while the other displayed preserved genetic polymorphisms and little genetic differentiation from its source population. Genes involved in G-protein coupled receptors and carbohydrate metabolism may contribute to the local adaptation of northern AHRs. In particular, RTN4 was identified as a key gene for AHRs in the QTP that favours adaptation to high-altitude hypoxia. Coincidently, the physiological performance and transcriptome profiles of hypoxia-exposed rats both showed better hypoxia adaptation in AHRs than in BRs that failed to colonize the heart of the QTP, which may have facilitated the replacement of the BR population by the invading AHRs at the edge of the QTP. This study provides profound insights into the multiple origins of the northwardly invasive AHR and the great tolerance to hypoxia in this species. |
| 源URL | [http://210.75.249.4/handle/363003/60685]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Chen, Yi,Hou, Guanmei,Jing, Meidong,et al. Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat[J]. MOLECULAR ECOLOGY,2021. |
| APA | Chen, Yi.,Hou, Guanmei.,Jing, Meidong.,Teng, Huajing.,Liu, Quansheng.,...&Zhang, Yaohua.(2021).Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat.MOLECULAR ECOLOGY. |
| MLA | Chen, Yi,et al."Genomic analysis unveils mechanisms of northward invasion and signatures of plateau adaptation in the Asian house rat".MOLECULAR ECOLOGY (2021). |
入库方式： OAI收割
来源：西北高原生物研究所
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