Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response
文献类型：期刊论文
| 作者 | Wang, Hailiang; Zhou, Jianhong; Bi, Hongtao; Yang, Xiaoyu; Chen, Wenlong; Jiang, Kuijun; Yao, Yang; Ni, Weihua |
| 刊名 | JOURNAL OF MEDICINAL FOOD
 |
| 出版日期 | 2021 |
| 卷号 | 24期号:7 |
| 关键词 | anti-inflammatory blood-brain barrier focal cerebral ischemia neuroprotection Nitraria tangutorun Bobr oxidative stress |
| 英文摘要 | Nitraria tangutorun Bobr. has been used for thousands of years as a native folk medicine to alleviate dizziness and neurasthenia due to oxygen. In our previous study, natural antioxidant components (namely, NJBE) were isolated from industrial N. tangutorun Bobr. juice byproducts (NJBE) from the Qinghai-Tibet plateau. The current investigation assessed the effects of NJBE on ischemic stroke in mice and the potential mechanisms. C57BL/6 mice received NJBE (25, 50, or 100 mg/Kg) by gavage for 14 days and then stroke was induced by the middle cerebral artery occlusion (MCAO) model, followed by reperfusion for 72 h. The evaluation of brain infarct size, behavioral tests, and functional assessments was conducted to assess the effects of NJBE after MCAO. Our results suggested that NJBE significantly decreases infarct size, improves neurological deficits, as well as reduces the number of GFAP(+) and Iba-1(+) cells after MCAO. NJBE inhibited nitric oxide and malondialdehyde production in the ischemic brain. Meanwhile, it attenuated the expressions of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Also, NJBE significantly attenuated the expression levels of proinflammatory indicators, including TNF-alpha, IL-1 beta, IL-6, and IL-12. This process was accompanied by the downregulation of TLR4, TRAF6, pI kappa B/pI kappa B, and MMP9 expression and the upregulation of claudin-5 expression. NJBE induced improvements in brain injury. The neuroprotective effect of NJBE provides evidence for its potential application in stroke treatment. |
| 源URL | [http://210.75.249.4/handle/363003/60779]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Wang, Hailiang,Zhou, Jianhong,Bi, Hongtao,et al. Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response[J]. JOURNAL OF MEDICINAL FOOD,2021,24(7). |
| APA | Wang, Hailiang.,Zhou, Jianhong.,Bi, Hongtao.,Yang, Xiaoyu.,Chen, Wenlong.,...&Ni, Weihua.(2021).Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response.JOURNAL OF MEDICINAL FOOD,24(7). |
| MLA | Wang, Hailiang,et al."Bioactive Ingredients from Nitraria tangutorun Bobr. Protect Against Cerebral Ischemia/Reperfusion Injury Through Attenuation of Oxidative Stress and the Inflammatory Response".JOURNAL OF MEDICINAL FOOD 24.7(2021). |
入库方式： OAI收割
来源：西北高原生物研究所
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