Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis
文献类型：期刊论文
| 作者 | Liu, Wenjing; Peng, Lei; Tian, Wanli; Li, Yi ; Zhang, Ping; Sun, Kuanxiang; Yang, Yeming; Li, Xiao; Li, Guisen; Zhu, Xianjun
|
| 刊名 | DISEASE MODELS & MECHANISMS
 |
| 出版日期 | 2021 |
| 卷号 | 14期号:6 |
| 关键词 | Tmem30a Albuminuria Focal segmental glomerulosclerosis Glomerulosclerosis |
| 英文摘要 | The asymmetric distribution of phosphatidylserine (PS) in the cytoplasmic leaflet of eukaryotic cell plasma membranes is regulated by a group of P4-ATPases (named PS flippases) and the 0-subunit TMEM30A. Podocytes in the glomerulus form a filtration barrier to prevent the traversing of large cellular elements and macromolecules from the blood into the urinary space. Damage to podocytes can disrupt the filtration barrier and lead to proteinuria and podocytopathy. We observed reduced TMEM30A expression in patients with minimal change disease and membranous nephropathy, indicating potential roles of TMEM30A in podocytopathy. To investigate the role of Tmem30a in the kidney, we generated a podocyte-specific Tmem30a knockout (KO) mouse model using the NPHS2-Cre line. Tmem30a KO mice displayed albuminuria, podocyte degeneration, mesangial cell proliferation with prominent extracellular matrix accumulation and eventual progression to focal segmental glomerulosclerosis. Our data demonstrate a critical role of Tmem30a in maintaining podocyte survival and glomerular filtration barrier integrity. Understanding the dynamic regulation of the PS distribution in the glomerulus provides a unique perspective to pinpointing the mechanism of podocyte damage and potential therapeutic targets. |
| 源URL | [http://210.75.249.4/handle/363003/60795]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Liu, Wenjing,Peng, Lei,Tian, Wanli,et al. Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis[J]. DISEASE MODELS & MECHANISMS,2021,14(6). |
| APA | Liu, Wenjing.,Peng, Lei.,Tian, Wanli.,Li, Yi.,Zhang, Ping.,...&Zhu, Xianjun.(2021).Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis.DISEASE MODELS & MECHANISMS,14(6). |
| MLA | Liu, Wenjing,et al."Loss of phosphatidylserine flippase beta-subunit Tmem30a in podocytes leads to albuminuria and glomerulosclerosis".DISEASE MODELS & MECHANISMS 14.6(2021). |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。