Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells
文献类型：期刊论文
| 作者 | Li, Ming; Sun, Pengcheng; Dong, Kaikai; Xin, Ye; TaiLulu, Aslee; Li, Qinyu; Sun, Jing ; Peng, Min; Shi, Ping
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| 刊名 | ARCHIVES OF PHARMACAL RESEARCH
 |
| 出版日期 | 2021 |
| 卷号 | 44期号:2 |
| 关键词 | Chemerin Human hepatic carcinoma SMMC7721 cells Cell proliferation Malignant phenotype Cell differentiation |
| 英文摘要 | Chemerin exhibits an inhibitory effect on hepatocellular carcinoma; however, the underlying mechanism is unclear. Here, low chemerin expression was confirmed in samples of liver cancer patients and hepatoma cells. Chemerin altered hepatoma cell morphology but had no effect on normal hepatocytes. Chemerin inhibited proliferation of several human hepatoma cell lines. Real-time PCR detection of hepatocellular carcinoma markers showed that mRNA levels of albumin and A-type gamma-glutamyl transferase increased whereas those of alpha-fetoprotein, alkaline phosphatase, B-type gamma-glutamyl transferase, insulin-like growth factor II, and human telomerase reverse transcriptase decreased in chemerin-treated SMMC7721 cells. Western blotting revealed that chemerin up-regulated albumin and vimentin expressions, and downregulated alpha-fetoprotein expression. Phosphorylated STAT3 was significantly up-regulated, whereas phosphorylated ERK and AKT were significantly downregulated by chemerin. Chemerin decreased phosphorylated ERK and AKT expression and the cell proliferation induced by PI3K activator 740 Y-P but could not significantly alter phosphorylated STAT3 expression and the cell growth induced by STAT3 inhibitor NSC74859. In conclusion, chemerin reversed the malignant phenotype and induced SMMC7721 cell differentiation by inhibiting MAPK/ERK and PI3K/AKT signaling; growth inhibition by chemerin is not directly related to the JAK/STAT signaling pathway. Our study provides novel evidence that chemerin could be utilized for liver cancer treatment. |
| 源URL | [http://210.75.249.4/handle/363003/60867]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Li, Ming,Sun, Pengcheng,Dong, Kaikai,et al. Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells[J]. ARCHIVES OF PHARMACAL RESEARCH,2021,44(2). |
| APA | Li, Ming.,Sun, Pengcheng.,Dong, Kaikai.,Xin, Ye.,TaiLulu, Aslee.,...&Shi, Ping.(2021).Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells.ARCHIVES OF PHARMACAL RESEARCH,44(2). |
| MLA | Li, Ming,et al."Chemerin reverses the malignant phenotype and induces differentiation of human hepatoma SMMC7721 cells".ARCHIVES OF PHARMACAL RESEARCH 44.2(2021). |
入库方式： OAI收割
来源：西北高原生物研究所
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