中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Combined everolimus and endocrine therapy in advanced HR-positive, HER2-negative Chinese breast cancer patients: a retrospective study

文献类型:期刊论文

作者Shen, Xia-Bo1,2; Li, Guang-Liang1,2; Zheng, Ya-Bing1,2; Chen, Zhan-Hong1,2; Cao, Wen-Ming1,2; Wang, Xiao-Jia1,2; Shao, Xi-Ying1,2
刊名ANNALS OF TRANSLATIONAL MEDICINE
出版日期2021-08-01
卷号9
关键词Advanced breast cancer (ABC) aromatase inhibitors (AIs) everolimus (EVE) fulvestrant (FUL) retrospective study
ISSN号2305-5839
DOI10.21037/atm-21-3840
通讯作者Wang, Xiao-Jia(wxiaojia0803@163.com) ; Shao, Xi-Ying(shaoxy@zjcc.org.cn)
英文摘要Background: Everolimus (EVE) is an inhibitor of the mammalian target of rapamycin (mTOR) pathway, and it is approved for the treatment of advanced breast cancer (ABC). However, there is still little real-world data on using EVE in Chinese breast cancer patients. We retrospectively analyzed real-world data to determine the factors affecting EVE treatment efficacy and patient outcomes. Methods: We retrospectively collected the treatment information of ABC patients treated with EVE from 2013 to 2020 in Zhejiang Cancer Hospital. Kaplan-Meier analysis and Cox regression methods were used to calculate and compare the progression-free survival (PFS), and identify the factors associated with EVE treatment efficacy. Results: The study finally enrolled 84 patients meeting the requirement; the median PFS in all 84 patients was 6.87 months. Multivariate analysis showed that liver metastasis [hazard ratio, 1.69; 95% confidence interval (CI), 1.00-2.84; P=0.049], and brain metastasis (hazard ratio, 2.65; 95% CI, 1.07-6.58; P=0.036) were independent risk factors. Subgroup analyses demonstrated EVE + fulvestrant (FUL) was not superior to EVE + aromatase inhibitors (AIs) for PFS (5.77 vs. 7.97 months, P=0.0735). Furthermore, it showed EVE + AI was superior to EVE + FUL in some subgroups: postmenopausal group (hazard ratio, 0.50; 95% CI, 0.26-0.98); without bone metastasis group (hazard ratio, 0.22; 95% CI, 0.06-0.80); visceral disease group (hazard ratio, 0.37; 95% CI, 0.20-0.69). Conclusions: EVE combined with endocrine therapy is an effective treatment option for Chinese patients with hormone-receptor-positive (HR+), human epidermal growth factor receptor-2-negative (HER2-) breast cancer, although EVE + FUL was not superior to EVE + AI. Liver metastasis and brain metastasis were independent risk factors for successful EVE + endocrine therapy.
WOS关键词PLUS EXEMESTANE ; AROMATASE INHIBITORS ; DOUBLE-BLIND ; FULVESTRANT ; MULTICENTER ; SAFETY
资助项目Zhejiang Provincial Research Center for Cancer Intelligent Diagnosis and Molecular Technology[JBZX-202003]
WOS研究方向Oncology ; Research & Experimental Medicine
语种英语
WOS记录号WOS:000687059100001
出版者AME PUBL CO
资助机构Zhejiang Provincial Research Center for Cancer Intelligent Diagnosis and Molecular Technology
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/125155]  
专题中国科学院合肥物质科学研究院
通讯作者Wang, Xiao-Jia; Shao, Xi-Ying
作者单位1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Breast Med Oncol, Hangzhou 310022, Peoples R China
2.Chinese Acad Sci, Inst Canc & Basic Med IBMC, Hangzhou, Peoples R China
推荐引用方式
GB/T 7714
Shen, Xia-Bo,Li, Guang-Liang,Zheng, Ya-Bing,et al. Combined everolimus and endocrine therapy in advanced HR-positive, HER2-negative Chinese breast cancer patients: a retrospective study[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9.
APA Shen, Xia-Bo.,Li, Guang-Liang.,Zheng, Ya-Bing.,Chen, Zhan-Hong.,Cao, Wen-Ming.,...&Shao, Xi-Ying.(2021).Combined everolimus and endocrine therapy in advanced HR-positive, HER2-negative Chinese breast cancer patients: a retrospective study.ANNALS OF TRANSLATIONAL MEDICINE,9.
MLA Shen, Xia-Bo,et al."Combined everolimus and endocrine therapy in advanced HR-positive, HER2-negative Chinese breast cancer patients: a retrospective study".ANNALS OF TRANSLATIONAL MEDICINE 9(2021).

入库方式: OAI收割

来源:合肥物质科学研究院

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