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The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures

文献类型：期刊论文

作者Lin, Dongyue1,2,3; He, Yao1; Dong, Ronglu1,2; Li, Wei1; Meng, Fanli4; Zhang, Yunfeng5; Yang, Liangbao1,3
刊名SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
出版日期2021-12-15
卷号263
关键词Surface enhanced Raman scattering High affinity Succinylcholine chloride Gold nanorods Human plasma
ISSN号1386-1425
DOI10.1016/j.saa.2021.120172
通讯作者Zhang, Yunfeng(17020395@qq.com) ; Yang, Liangbao(lbyang@iim.ac.cn)
英文摘要Succinylcholine chloride (SCC) is a common poison that threatens human life. At present, there is a lack of research on its on-site rapid detection methods. In this work, the use of gold nanorods as an enhanced substrate based on the high affinity between the quaternary ammonium salt structure can achieve rapid SERS detection of SCC in plasma. The long alkane chain structure of cetyltrimethylammonium bromide (CTAB) and the quaternary ammonium salt structure of SCC have a high molecular affinity, so that the target molecule can show a strong and obvious characteristic signal of SERS. Combined with a simple pretreatment method, acetonitrile is used as a protein precipitation agent to effectively remove matrix interference. The constructed SERS substrate can achieve the sensitive detection of 2 x 10(-8) M level of SCC in plasma samples and has high detection reproducibility. The entire pre-processing and testing process can be completed within 7 min, which can be used as an important technical basis for the preliminary identification of on-site SCC-related drug cases. The research results provide an effective solution for the establishment of SCC analysis strategies in complex matrices, and can provide new ideas for solving the problems of difficult identification of common poisons in the field and the lack of rapid detection methods on site. (C) 2021 Elsevier B.V. All rights reserved.
WOS关键词ENHANCED RAMAN-SPECTROSCOPY ; REFLECTANCE INFRARED MICROSPECTROSCOPY ; SENSITIVE DETECTION ; SCATTERING ; CHOLINE ; NANOPARTICLES ; MOLECULES ; PROTEIN ; METAL
资助项目National Science Foundation of China[61605221] ; National Science Foundation of China[21974142] ; National Science Foundation of China[62033002] ; Open project of Beijing Engineering Technology Research Center for On-site Evidence Inspection[2020CSEEKFKT07]
WOS研究方向Spectroscopy
语种英语
WOS记录号WOS:000691514800023
出版者PERGAMON-ELSEVIER SCIENCE LTD
资助机构National Science Foundation of China ; Open project of Beijing Engineering Technology Research Center for On-site Evidence Inspection
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/125183]  
专题中国科学院合肥物质科学研究院
通讯作者Zhang, Yunfeng; Yang, Liangbao
作者单位1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Hefei 230031, Peoples R China
2.Univ Sci & Technol China, Hefei 230026, Peoples R China
3.Chinese Acad Sci, Hefei Canc Hosp, Dept Pharm, Hefei 230031, Peoples R China
4.Northeastern Univ, Shenyang 110819, Peoples R China
5.Inst Forens Sci, Minist Publ Secur, Beijing 100038, Peoples R China
推荐引用方式
GB/T 7714		 Lin, Dongyue,He, Yao,Dong, Ronglu,et al. The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2021,263.
APA Lin, Dongyue.,He, Yao.,Dong, Ronglu.,Li, Wei.,Meng, Fanli.,...&Yang, Liangbao.(2021).The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,263.
MLA Lin, Dongyue,et al."The rapid SERS detection of succinylcholine chloride in human plasma is based on the high affinity between quaternary ammonium salt structures".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 263(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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