Inokosterone Is A Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients: Analysis from Active Ingredient of Cyathula Officinalis
文献类型：期刊论文
| 作者 | Mo, Ji-hao1; Xie, Han-kun2; Zhou, Ye-mian3; Ng, Sihan-benjamin4; Li, Shao-xia1; Wang, Lei2 |
| 刊名 | CHINESE JOURNAL OF INTEGRATIVE MEDICINE
 |
| 出版日期 | 2021-08-25 |
| 关键词 | rheumatoid arthritis estrogen receptor 1 inokosterone Cyathula Officinalis Chinese medicine |
| ISSN号 | 1672-0415 |
| DOI | 10.1007/s11655-021-3492-5 |
| 通讯作者 | Wang, Lei(lxw561@miami.edu) |
| 英文摘要 | Objective To elucidate the active compounds and the molecular mechanism of Cyathula Officinalis as a drug treatment for rheumatoid arthritis (RA). Methods The target genes of active ingredients from Cyathula Officinalis were obtained from bioinformatics analysis tool for the molecular mechanism of traditional Chinese medicine. The protein-protein interaction between the target genes were analyzed using STRING and Genemania. The transcriptome of RA patients compared to healthy people (GSE121894) were analyzed using R program package Limma. The relative expression of the target genes was obtained from the RNA-seq datasets. The molecular docking analyses were processed based on the molecular model of estrogen receptor 1 (ESR1) binding with estradiol (PDB ID:1A52). The binding details were analyzed by SYBYL. Results Inokosterone, ecdysterone, and cyaterone were the 3 active ingredients from Cyathula Officinalis that bind to target genes. Of all the significantly changed genes from RA patients, ESR1, ADORA1, and ANXA1 were significantly increased in mRNA samples of RA patients. Conclusion ESR1, the transcription factor that binds inokosterone in the molecular binding analysis, is the target protein of Cyathula Officinalis. |
| WOS关键词 | MEDICINE ; ESR1 |
| WOS研究方向 | Integrative & Complementary Medicine |
| 语种 | 英语 |
| WOS记录号 | WOS:000688388500003 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125187]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wang, Lei |
| 作者单位 | 1.Luoyang Orthoped Hosp Henan Prov, Orthoped Inst Henan Prov, Dept Lab Med, Luoyang 471002, Henan, Peoples R China 2.Univ Miami, Miller Sch Med, Miami, FL 33136 USA 3.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Tech Biol & Agr Engn, Hefei 230031, Peoples R China 4.Eatobe Pte Ltd, Singapore 573969, Singapore |
| 推荐引用方式 GB/T 7714 | Mo, Ji-hao,Xie, Han-kun,Zhou, Ye-mian,et al. Inokosterone Is A Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients: Analysis from Active Ingredient of Cyathula Officinalis[J]. CHINESE JOURNAL OF INTEGRATIVE MEDICINE,2021. |
| APA | Mo, Ji-hao,Xie, Han-kun,Zhou, Ye-mian,Ng, Sihan-benjamin,Li, Shao-xia,&Wang, Lei.(2021).Inokosterone Is A Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients: Analysis from Active Ingredient of Cyathula Officinalis.CHINESE JOURNAL OF INTEGRATIVE MEDICINE. |
| MLA | Mo, Ji-hao,et al."Inokosterone Is A Potential Drug Target of Estrogen Receptor 1 in Rheumatoid Arthritis Patients: Analysis from Active Ingredient of Cyathula Officinalis".CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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