3D-printed smartphone-based device for fluorimetric diagnosis of ketosis by acetone-responsive dye marker and red emissive carbon dots
文献类型：期刊论文
| 作者 | Yang, Fan1,2; Yang, Linlin1,3; Xu, Longchang1; Guo, Wei1,2; Pan, Lei1,2; Zhang, Chuanglin1; Xu, Shihao1,4; Zhang, Ningning5; Yang, Liang1,4; Jiang, Changlong1,4
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| 刊名 | MICROCHIMICA ACTA
 |
| 出版日期 | 2021-09-01 |
| 卷号 | 188 |
| ISSN号 | 0026-3672 |
| 关键词 | Smartphone-based device Real-time monitoring Ratiometric fluorescence Subhealth recognition Acetone detection Health warning |
| DOI | 10.1007/s00604-021-04965-0 |
| 通讯作者 | Yang, Liang() ; Jiang, Changlong(cljiang@iim.ac.cn) |
| 英文摘要 | A portable smartphone device is reported that uses 3D printing technology for the primary diagnosis of diseases by detecting acetone. The key part of the device consists of red carbon dots (RCDs), which are used as internal standards, and a sensing reagent (3-N,N-(diacethydrazide)-9-ethylcarbazole (2-HCA)) for acetone. With an excitation wavelength of 360 nm, the emission wavelengths of 2-HCA and RCDs are 443 nm and 619 nm, respectively. 2-HCA effectively captures acetone to form a nonfluorescent acylhydrazone via a condensation reaction occurring in aqueous solution, resulting in obvious color changes from blue-violet to dark red. The detection limit for acetone is 2.62 mu M (similar to 0.24 ppm). This is far lower than the ketone content in normal human blood (<= 0.50 mM) and the acetone content in human respiratory gas (<= 1.80 ppm). The device has good recovery rates for acetone detection in blood and exhaled breath, which are 90.56-109.98% (RSD <= 5.48) and 92.80-108.00% (RSD <= 5.07), respectively. The method designed here provides a reliable way to provide health warnings by visually detecting markers of ketosis/diabetes in blood or exhaled breath. |
| WOS关键词 | FLUORESCENT TEST PAPER ; BREATH ANALYSIS ; LUMINESCENCE ; DISEASE ; SCALE |
| 资助项目 | National Natural Science Foundation of China[21671052] ; National Natural Science Foundation of China[21806168] ; Key Research and Development Program of Anhui Province[202004d07020013] ; Key Research and Development Program of Anhui Province[1804a07020103] ; Natural Science Foundation of Anhui Province[2008085QB69] ; Scientific Research Foundation for High-Level Talents of West Anhui University[WGKQ2021001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | SPRINGER WIEN |
| WOS记录号 | WOS:000690901800003 |
| 资助机构 | National Natural Science Foundation of China ; Key Research and Development Program of Anhui Province ; Natural Science Foundation of Anhui Province ; Scientific Research Foundation for High-Level Talents of West Anhui University |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125189]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Yang, Liang; Jiang, Changlong |
| 作者单位 | 1.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Solid State Phys, Hefei 230031, Anhui, Peoples R China 2.Univ Sci & Technol China, Dept Chem, Hefei 230026, Peoples R China 3.West Anhui Univ, Sch Mat & Chem Engn, Key Lab Biomimet Sensor & Detecting Technol Anhui, Luan 237012, Anhui, Peoples R China 4.Chinese Acad Sci, State Key Lab Transducer Technol, Hefei 230031, Anhui, Peoples R China 5.Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, Fan,Yang, Linlin,Xu, Longchang,et al. 3D-printed smartphone-based device for fluorimetric diagnosis of ketosis by acetone-responsive dye marker and red emissive carbon dots[J]. MICROCHIMICA ACTA,2021,188. |
| APA | Yang, Fan.,Yang, Linlin.,Xu, Longchang.,Guo, Wei.,Pan, Lei.,...&Jiang, Changlong.(2021).3D-printed smartphone-based device for fluorimetric diagnosis of ketosis by acetone-responsive dye marker and red emissive carbon dots.MICROCHIMICA ACTA,188. |
| MLA | Yang, Fan,et al."3D-printed smartphone-based device for fluorimetric diagnosis of ketosis by acetone-responsive dye marker and red emissive carbon dots".MICROCHIMICA ACTA 188(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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