Pulmonary enteric adenocarcinoma
文献类型：期刊论文
| 作者 | Gong, Jiali1,2,3,4; Fan, Ying2,3,4,5; Lu, Hongyang1,2,3,4 |
| 刊名 | TRANSLATIONAL ONCOLOGY
 |
| 出版日期 | 2021-08-01 |
| 卷号 | 14 |
| 关键词 | PEAC Immunohistochemistry Mutation analysis Diagnosis Prognosis |
| ISSN号 | 1936-5233 |
| DOI | 10.1016/j.tranon.2021.101123 |
| 通讯作者 | Lu, Hongyang(luhy@zjcc.org.cn) |
| 英文摘要 | Pulmonary enteric adenocarcinoma (PEAC) is an exceptionally rare subtype of non-small cell lung cancer (NSCLC). It is characterized by pathological features similar to those of colorectal adenocarcinoma. Most patients with PEAC have almost no special clinical manifestations, and it is often difficult to differentiate from metastatic colorectal adenocarcinoma (MCRC). As a special type of lung adenocarcinoma, PEAC has unique mutation expres-sion and immune characteristics; its mutation profile shows higher Kirsten rat sarcoma viral oncogene (KRAS), human epidermal growth factor receptor-2 (HER2) , DNA mismatch repair(MMR) mutation rates, and much lower epidermal growth factor receptor (EGFR) rate. So in the future, targeted therapy may tend to be a new light in the treatment of PEAC. As for immunohistochemistry (IHC), CDX-2, villin, and CK7 are significantly positive in PEAC. This review focuses on the pathologic features, immunohistochemical examination, mutation analysis, diagnosis, treatment, and prognosis of PEAC. |
| WOS关键词 | CDX-2 HOMEOBOX GENE ; INTESTINAL-TYPE ; LUNG ; EXPRESSION ; CARCINOMAS ; DIFFERENTIATION ; MARKER ; CANCER ; SATB2 ; CYTOKERATIN-20 |
| 资助项目 | Zhejiang Province Medical Science and Technology Project[2020ZH001] ; CSCO Haosen Cancer Research Foundation[Y-HS2017-044] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000687271300017 |
| 出版者 | ELSEVIER SCIENCE INC |
| 资助机构 | Zhejiang Province Medical Science and Technology Project ; CSCO Haosen Cancer Research Foundation |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125235]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Lu, Hongyang |
| 作者单位 | 1.Zhejiang Chinese Med Univ, Clin Med Coll 2, Hangzhou 310053, Peoples R China 2.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Zhejiang Key Lab Diag & Treatment Technol Thorac, Hangzhou 310022, Zhejiang, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Thorac Med Oncol, Hangzhou 310022, Zhejiang, Peoples R China 4.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou 310022, Zhejiang, Peoples R China 5.Wenzhou Med Univ, Clin Med Coll 1, Wenzhou 325035, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gong, Jiali,Fan, Ying,Lu, Hongyang. Pulmonary enteric adenocarcinoma[J]. TRANSLATIONAL ONCOLOGY,2021,14. |
| APA | Gong, Jiali,Fan, Ying,&Lu, Hongyang.(2021).Pulmonary enteric adenocarcinoma.TRANSLATIONAL ONCOLOGY,14. |
| MLA | Gong, Jiali,et al."Pulmonary enteric adenocarcinoma".TRANSLATIONAL ONCOLOGY 14(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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