E2F1/2/4 mRNA is associated with immune infiltration and are potential biomarkers for the prognosis of human gastric carcinoma
文献类型：期刊论文
| 作者 | Chen, Yongyi1,2; Gong, Wangang2,3; Dai, Wumin2,3; Jiang, Huifen1,2; Xu, Xiaohong1,2 |
| 刊名 | TRANSLATIONAL CANCER RESEARCH
 |
| 出版日期 | 2021-06-01 |
| 卷号 | 10 |
| 关键词 | E2F1/2/4 gastric cancer (GC) immune infiltration bioinformatics analysis |
| ISSN号 | 2218-676X |
| DOI | 10.21037/tcr-21-45 |
| 通讯作者 | Xu, Xiaohong(zjhzxxh@163.com) |
| 英文摘要 | Background: E2Fs are genes that regulate DNA synthesis and the cell cycle by encoding a family of transcription factors. Increasing experimental evidence has revealed that E2Fs play key roles in tumor progression in various types of cancer. Methods: We investigated the survival, expression and transcriptional data of E2F1/2/4 in gastric cancer (GC) patients using the immunohistochemistry assay, Kaplan-Meier Plotter, cBioPortal, String, and GEPIA databases. The plasma of GC patients was analyzed using the real-time reverse transcription polymerase chain reaction (RT- PCR) assay. The correlation between E2F1/2/4 expression and clinical features was analyzed using the quartile method. As well, the correlation between E2F1/2/4 and GC immune infiltration was also investigated using the TIMER database. Database of Immune Cell Expression (DICE) was also used to analyze correlations between SOX4 and immune responses. Results: RT- PCR and tissue immunohistochemistry confirmed that E2F1/2/4 was highly expressed in serum and GC tissue samples of GC patients, the expression of which was not affected by patient age and gender. Also, the survival analysis revealed that low levels of E2F1/ 2/4 expression were significantly associated with a longer overall survival (OS) in GC patients. E2F1/2/4 was correlated with patient prognosis and immune cell infiltration, including B cells, CD8(+) T cells, CD4(+) T cells, macrophages, neutrophils, and DCs in GC. Our findings indicated that E2F1/2/4 could be used as a prognostic biomarker and indicator of immune infiltration in GC. Conclusions: This study revealed that E2F1/2/4 could be a promising indicator for tumor-associated immune infiltration and prognosis in GC patients. |
| WOS关键词 | SQUAMOUS-CELL CARCINOMA ; TRANSCRIPTION FACTORS ; CLINICAL-RELEVANCE ; E2F FAMILY ; CANCER ; EXPRESSION ; GENE ; RISK |
| 资助项目 | Zhejiang Province Public Welfare Technology Application Research Project[2021KY082] |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000694025800015 |
| 出版者 | AME PUBL CO |
| 资助机构 | Zhejiang Province Public Welfare Technology Application Research Project |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125305]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Xu, Xiaohong |
| 作者单位 | 1.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Dept Clin Lab, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Canc Hosp, Zhejiang Canc Res Inst, Hangzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yongyi,Gong, Wangang,Dai, Wumin,et al. E2F1/2/4 mRNA is associated with immune infiltration and are potential biomarkers for the prognosis of human gastric carcinoma[J]. TRANSLATIONAL CANCER RESEARCH,2021,10. |
| APA | Chen, Yongyi,Gong, Wangang,Dai, Wumin,Jiang, Huifen,&Xu, Xiaohong.(2021).E2F1/2/4 mRNA is associated with immune infiltration and are potential biomarkers for the prognosis of human gastric carcinoma.TRANSLATIONAL CANCER RESEARCH,10. |
| MLA | Chen, Yongyi,et al."E2F1/2/4 mRNA is associated with immune infiltration and are potential biomarkers for the prognosis of human gastric carcinoma".TRANSLATIONAL CANCER RESEARCH 10(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。