Circulating C-reactive protein increases lung cancer risk: Results from a prospective cohort of UK Biobank
文献类型：期刊论文
| 作者 | Ji, Mengmeng1,2; Du, Lingbin3,4; Ma, Zhimin1,2; Xie, Junxing2; Huang, Yanqian2; Wei, Xiaoxia2; Jiang, Xiangxiang2; Xu, Jing5; Yin, Rong6; Wang, Yuzhuo2,6 |
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2021-09-09 |
| ISSN号 | 0020-7136 |
| 关键词 | C-reactive protein chronic inflammation lung cancer Mendelian randomization prediagnostic marker |
| DOI | 10.1002/ijc.33780 |
| 通讯作者 | Zhu, Meng(zhmnjmu@njmu.edu.cn) ; Shen, Hongbing(hbshen@njmu.edu.cn) |
| 英文摘要 | Chronic inflammation has been associated with the development of lung cancer. In this study, we examined the association between C-reactive protein (CRP) and lung cancer in a prospective cohort study and used Mendelian randomization (MR) to clarify the causality. We included 420 977 participants from the UK Biobank (UKB) in the analyses; 1892 thereof were diagnosed with lung cancer during the follow-up. Hazards ratios (HRs) of CRP concentrations were estimated by Cox proportional hazard models and two approaches of MR analysis were performed. Besides, we added CRP concentrations to epidemiological model of lung cancer to evaluate its prediagnostic role through time-dependent receiver operating characteristic curve analysis. Elevated CRP levels were associated with a 22% increased lung cancer risk per 1 SD increase (HR = 1.22, 95% confidence interval [CI] = 1.18-1.26). Positive associations were observed in small cell lung cancer (HR = 1.21, 95% CI = 1.10-1.33), lung adenocarcinoma (HR = 1.17, 95% CI = 1.11-1.23) and lung squamous cell carcinoma (HR = 1.22, 95% CI = 1.14-1.31). No genetical association of circulating CRP levels and lung cancer risk was observed in MR analysis. When added to a risk model of lung cancer, CRP improved the performance of model as long as 8 years among current smokers (basic model: C-statistic = 0.78 [95% CI = 0.75-0.80]; CRP model: C-statistic = 0.79 [95% CI = 0.76-0.81]; P-nonadjusted = .003, P-adjusted = .014). Our results did not support the causal association of circulating CRP with lung cancer risk. However, circulating CRP could be a prediagnostic marker of lung cancer as long as 8 years in advance for current smokers. |
| WOS关键词 | DENSITY-LIPOPROTEIN CHOLESTEROL ; CORONARY-HEART-DISEASE ; MENDELIAN RANDOMIZATION ; INFLAMMATION ; MARKERS ; EPIDEMIOLOGY ; PARTICIPANTS ; ASSOCIATION ; PATHWAYS ; RESOURCE |
| 资助项目 | This work was supported by National Key Research and Development Program of China (2018YFC1315002, 2017YFC0907905); Natural Science Foundation of Jiangsu Province (BK20180675); National Natural Science Foundation of China (81803306, 81973123, 81922061, 81521004); National Science Foundation for Post-doctoral Scientists of China (2018M640466) and CAMS Innovation Fund for Medical Sciences (2019RU038) |
| WOS研究方向 | Oncology |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000694650900001 |
| 资助机构 | This work was supported by National Key Research and Development Program of China (2018YFC1315002, 2017YFC0907905); Natural Science Foundation of Jiangsu Province (BK20180675); National Natural Science Foundation of China (81803306, 81973123, 81922061, 81521004); National Science Foundation for Post-doctoral Scientists of China (2018M640466) and CAMS Innovation Fund for Medical Sciences (2019RU038) |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125307]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhu, Meng; Shen, Hongbing |
| 作者单位 | 1.Southeast Univ, Sch Publ Hlth, Dept Epidemiol, Nanjing, Peoples R China 2.Nanjing Med Univ, Ctr Global Hlth, Sch Publ Hlth, Dept Epidemiol, 101 Longmian Rd, Nanjing 211166, Peoples R China 3.Univ Chinese Acad Sci, Dept Canc Prevent, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China 4.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Hangzhou, Peoples R China 5.Nanjing Med Univ, Dept Thorac Surg, Affiliated Hosp 1, Nanjing, Peoples R China 6.Nanjing Med Univ, Jiangsu Key Lab Mol & Translat Canc Res, Jiangsu Inst Canc Res, Dept Thorac Surg,Jiangsu Canc Hosp,Affiliated Can, Nanjing, Peoples R China 7.Nanjing Med Univ, Collaborat Innovat Ctr Canc Personalized Med, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Nanjing, Peoples R China 8.Chinese Acad Med Sci, Res Units Cohort Study Cardiovasc Dis & Canc, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Mengmeng,Du, Lingbin,Ma, Zhimin,et al. Circulating C-reactive protein increases lung cancer risk: Results from a prospective cohort of UK Biobank[J]. INTERNATIONAL JOURNAL OF CANCER,2021. |
| APA | Ji, Mengmeng.,Du, Lingbin.,Ma, Zhimin.,Xie, Junxing.,Huang, Yanqian.,...&Shen, Hongbing.(2021).Circulating C-reactive protein increases lung cancer risk: Results from a prospective cohort of UK Biobank.INTERNATIONAL JOURNAL OF CANCER. |
| MLA | Ji, Mengmeng,et al."Circulating C-reactive protein increases lung cancer risk: Results from a prospective cohort of UK Biobank".INTERNATIONAL JOURNAL OF CANCER (2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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