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Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed

文献类型：期刊论文

作者Liu, Fang1,2; Bao, Jie1,3; Chen, Jinwu1,4; Song, Wencheng1,3,5,6
刊名JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
出版日期2021-09-18
关键词I-125 seed Transcriptome Inhibitory mechanism A549 cells
ISSN号0236-5731
DOI10.1007/s10967-021-07984-6
通讯作者Chen, Jinwu(yunliuqiye@163.com) ; Song, Wencheng(wencsong@cmpt.ac.cn)
英文摘要In this study, A549 cells treated by radioactive I-125 seed were sequenced using Illumina HiSeq PE150, and then the transcriptome was analyzed using bioinformatics methods. Gene ontology classification analysis showed that differentially expressed genes (DEGs) belonged to 10 categories, and low-dose group, medium-dose group and high-dose group I-125 treatment obtained 440 DEGs, 4275 DEGs and 2850 DEGs, respectively. Additionally, DEGs were involved in tumor-related pathways, endoplasmic reticulum protein processing and cell cycle pathways. Therefore, radioactive I-125 seed can significantly inhibit the growth of lung cancer, which provide a theoretical basis for the clinical I-125 seed to effectively treat lung cancer.
WOS关键词AMERICAN BRACHYTHERAPY ; RADIATION ; IMPLANTATION ; IRRADIATION ; EXPRESSION ; APOPTOSIS ; TUMORS
资助项目National Natural Science Foundation of China[21876179] ; National Natural Science Foundation of China[22142007] ; National Natural Science Foundation of China[22006001] ; Natural Science Foundation of Anhui Province[1808085QA13] ; Natural Science Foundation of Anhui Province[2008085MC65] ; China Postdoctoral Science Foundation[2020T130117ZX] ; China Postdoctoral Science Foundation[2020M671914] ; China Postdoctoral Science Foundation[2020B470] ; Natural Science Foundation of Anhui Higher Education Institutions[KJ2017A935]
WOS研究方向Chemistry ; Nuclear Science & Technology
语种英语
WOS记录号WOS:000697093300004
出版者SPRINGER
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Anhui Province ; China Postdoctoral Science Foundation ; Natural Science Foundation of Anhui Higher Education Institutions
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/125313]  
专题中国科学院合肥物质科学研究院
通讯作者Chen, Jinwu; Song, Wencheng
作者单位1.Chinese Acad Sci, Inst Hlth & Med Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
2.Anhui Univ, Sch Life Sci, Hefei 230036, Peoples R China
3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
4.Hefei Normal Univ, Hefei 230061, Anhui, Peoples R China
5.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Jiangsu Higher Educ Inst, Suzhou 215123, Peoples R China
6.Soochow Univ, Sch Radiol & Interdisciplinary Sci, Suzhou 215123, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Fang,Bao, Jie,Chen, Jinwu,et al. Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed[J]. JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY,2021.
APA Liu, Fang,Bao, Jie,Chen, Jinwu,&Song, Wencheng.(2021).Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed.JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY.
MLA Liu, Fang,et al."Comparative transcriptome analysis providing inhibitory mechanism of lung cancer A549 cells by radioactive I-125 seed".JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY (2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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