Non-invasive skin cholesterol testing: a potential proxy for LDL-C and apoB serum measurements
文献类型：期刊论文
| 作者 | Lai, Jiacheng1,2; Han, Yongsheng1; Huang, Chongjian1; Li, Bin1; Ni, Jingshu3; Dong, Meili3 ; Wang, Yikun3; Wang, Qingtong4
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| 刊名 | LIPIDS IN HEALTH AND DISEASE
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| 出版日期 | 2021-10-17 |
| 卷号 | 20 |
| 关键词 | Lipid management LDL-C apoB Skin cholesterol Low initial LDL-C |
| DOI | 10.1186/s12944-021-01571-0 |
| 通讯作者 | Han, Yongsheng(hanysh1017@163.com) ; Wang, Qingtong(hfwqt727@163.com) |
| 英文摘要 | Background Lipid management is the first line of treatment for decreasing the incidence of cardiovascular events in patients with coronary heart disease (CHD), and a variety of indicators are used to evaluate lipid management. This work analyses the differences in LDL-C and apoB for lipid management evaluation, as well as explores the feasibility of skin cholesterol as a marker that can be measured non-invasively for lipid management. Methods The prospective study enrolled 121 patients who had been diagnosed with acute coronary syndrome (ACS) at the department of emergency medicine of the First Affiliated Hospital of the USTC from May 2020 to January 2021, and the patients were grouped into Group I (n=53) and Group II (n=68) according to whether they had comorbid hyperlipidemia and/or diabetes mellitus. All patients were administered 10 mg/day of rosuvastatin and observed for 12 weeks. Lipid management was assessed on the basis of LDL-C and apoB, and linear correlation models were employed to assess the relationship between changes in these well accepted markers to that of changes in skin cholesterol. Results Out of 121 patients with ACS, 53 patients (43.80 %) had combined hyperlipidemia and/or diabetes mellitus (Group I), while 68 patients (56.20 %) did not (Group II). Cardiovascular events occur at earlier ages in patients with CHD who are comorbid for hyperlipidemia and/or diabetes (P<0.05). LDL-C attainment rate is lower than apoB attainment rate with rosuvastatin therapy (P<0.05), which is mainly attributable to patients with low initial LDL-C. Skin cholesterol reduction correlated with LDL-C reduction. (r=0.501, P<0.001) and apoB reduction (r=0.538, P<0.001). Skin cholesterol reduction continued over all time points measured. Conclusions Examination of changes in apoB levels give patients with low initial LDL-C more informative data on lipid management than LDL-C readings. In addition, non-invasive skin cholesterol measurements may have the potential to be used independently for lipid management evaluation. |
| WOS关键词 | APOLIPOPROTEIN-B ; RISK ; ATHEROSCLEROSIS |
| 资助项目 | National Natural Science Foundation of China[81973314] ; Key Research and Development Program of Anhui Province[1804h08020291] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| 语种 | 英语 |
| WOS记录号 | WOS:000707839800001 |
| 出版者 | BMC |
| 资助机构 | National Natural Science Foundation of China ; Key Research and Development Program of Anhui Province |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125587]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Han, Yongsheng; Wang, Qingtong |
| 作者单位 | 1.Univ Sci & Technol China, Div Life Sci & Med, Affiliated Hosp USTC 1, Dept Emergency Med, Hefei, Peoples R China 2.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Emergency & Trauma Ctr,Int Med Ctr, Hangzhou, Peoples R China 3.Chinese Acad Sci, Anhui Inst Opt & Fine Mech, Hefei Inst Phys Sci, Anhui Prov Engn Technol Res Ctr Biomed Opt Instru, Hefei 230031, Peoples R China 4.Anhui Med Univ, Collaborat Innovat Ctr Antiinflammatory & Immune, Inst Clin Pharmacol, Key Lab Antiinflammatory & Immune Med,Minist Educ, Hefei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lai, Jiacheng,Han, Yongsheng,Huang, Chongjian,et al. Non-invasive skin cholesterol testing: a potential proxy for LDL-C and apoB serum measurements[J]. LIPIDS IN HEALTH AND DISEASE,2021,20. |
| APA | Lai, Jiacheng.,Han, Yongsheng.,Huang, Chongjian.,Li, Bin.,Ni, Jingshu.,...&Wang, Qingtong.(2021).Non-invasive skin cholesterol testing: a potential proxy for LDL-C and apoB serum measurements.LIPIDS IN HEALTH AND DISEASE,20. |
| MLA | Lai, Jiacheng,et al."Non-invasive skin cholesterol testing: a potential proxy for LDL-C and apoB serum measurements".LIPIDS IN HEALTH AND DISEASE 20(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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