Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe
文献类型：期刊论文
| 作者 | Li, Dandan1,2; Tian, Xiaohe1,2; Liu, Zhengjie1,2,3; Liu, Jiejie1,2; Han, Guangmei1,2,3; Liu, Bianhua4; Zhao, Jun4; Zhang, Ruilong1,2,3; Tian, Yupeng1,2,3; Zhang, Zhongping1,2,3
|
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2021-10-12 |
| 卷号 | 93 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.1c03109 |
| 通讯作者 | Zhang, Ruilong(zrl@ahu.edu.cn) |
| 英文摘要 | Understanding signaling molecules in regulating organelles dynamics and programmed cell death is critical for embryo development but chameleon-like probe is also challenging because current imaging probes are incapable of simultaneously imaging the signaling molecules and the intracellular organelles they interact with. Here, we report a chemically and environmentally dual-responsive imaging probe that can react with gasotransmitters and label cell nuclei in distinctive fluorescent colors, similar to the adaptive coloration of chameleons. Using this intracellular chameleon-like probe in three-dimensional (3D) super-resolution dynamic imaging of live cells, we discovered SO2 as a critical upstream signaling molecule that activates nucleophagy in programmed cell death. An elevated level of SO2 prompts kiss fusion between the lysosomal and nuclear membranes and nucleus shrinkage and rupture. Significantly, we revealed that the gasotransmitter SO2 is majorly generated in the yolk, induces autophagy there at the initial stage of embryo development, and is highly related to the development of the auditory nervous system. |
| WOS关键词 | PROGRAMMED CELL-DEATH ; LIVING CELLS ; COMPLEX |
| 资助项目 | National Natural Science Foundation of China[21775001] ; National Natural Science Foundation of China[21871003] ; National Natural Science Foundation of China[21974001] ; National Natural Science Foundation of China[21976183] ; National Natural Science Foundation of China[22074001] ; National Natural Science Foundation of China[22171001] ; Anhui Provincial Natural Science Foundation of China[1808085MB32] ; Anhui Provincial Natural Science Foundation of China[2108085MB49] ; Science and Technology Service Network Initiative of the Chinese Academy of China[KFJ-STS-ZDTP-080] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000708550500032 |
| 资助机构 | National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation of China ; Science and Technology Service Network Initiative of the Chinese Academy of China |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125603]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Zhang, Ruilong |
| 作者单位 | 1.Anhui Univ, Sch Chem & Chem Engn, Informat Mat & Intelligent Sensing Lab Anhui Prov, Hefei 230601, Peoples R China 2.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 3.Anhui Univ, Key Lab Struct & Funct Regulat Hybrid Mat, Minist Educ, Hefei 230601, Anhui, Peoples R China 4.Chinese Acad Sci, Inst Solid State Phys, Key Lab Photovolta & Energy Conservat Mat, HFIPS, Hefei 230031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Dandan,Tian, Xiaohe,Liu, Zhengjie,et al. Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe[J]. ANALYTICAL CHEMISTRY,2021,93. |
| APA | Li, Dandan.,Tian, Xiaohe.,Liu, Zhengjie.,Liu, Jiejie.,Han, Guangmei.,...&Zhang, Zhongping.(2021).Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe.ANALYTICAL CHEMISTRY,93. |
| MLA | Li, Dandan,et al."Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe".ANALYTICAL CHEMISTRY 93(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。