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Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy

文献类型：期刊论文

作者Cai, Ren1; Xiang, Huandong2; Yang, Dan3; Lin, Keng-Te3; Wu, Yuanzheng2; Zhou, Ruyi2; Gu, Zhanjun2,4; Yan, Liang2,4; Zhao, Yuliang2,8; Tan, Weihong1,5,6,7
刊名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
出版日期2021-10-06
卷号143
ISSN号0002-7863
DOI10.1021/jacs.1c06652
通讯作者Yan, Liang(yanliang@ihep.ac.cn) ; Zhao, Yuliang(zhaoyl@nanoctr.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要Integrating multifunctional nanostructures capable of radiotherapy and photothermal ablation is an emerging alternative in killing cancer cells. In this work, we report a novel plasmonic heterostructure formed by decorating AuPt nano-particles (NPs) onto the surfaces of CuS nanosheets (AuPt@ CuS NSs) as a highly effective nanotheranostic toward dual-modal photoacoustic/computed tomography imaging and enhanced synergistic radiophotothermal therapy. These heterostructures can confer higher photothermal conversion efficiency via the local electromagnetic enhancement as well as a greater radiation dose deposition in the form of glutathione depletion and reactive oxygen species generation. As a result, the depth of tissue penetration is improved, and hypoxia of the tumor microenvironment is alleviated. With synergistic enhancement in the efficacy of photothermal ablation and radiotherapy, the tumor can be eliminated without later recurrence. It is believed that these multifunctional heterostructures will play a vital role in future oncotherapy with the enhanced synergistic effects of radiotherapy and photothermal ablation under the guided imaging of a potential dual-modality system.
WOS关键词COPPER SULFIDE NANOPARTICLES ; REDUCED GRAPHENE OXIDE ; PHOTOTHERMAL THERAPY ; NANOCRYSTALS ; SURFACE ; LIGHT ; RADIOTHERAPY ; ABSORPTION ; NANOMATERIALS ; SPECTROSCOPY
资助项目National Key Research and Development Program of China[2016YFE0133100] ; National Nature Science Foundation of China[21521063] ; National Nature Science Foundation of China[22004032] ; National Nature Science Foundation of China[32071403] ; National Nature Science Foundation of China[51822207]
WOS研究方向Chemistry
语种英语
出版者AMER CHEMICAL SOC
WOS记录号WOS:000706193200022
资助机构National Key Research and Development Program of China ; National Nature Science Foundation of China
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/125633]  
专题中国科学院合肥物质科学研究院
通讯作者Yan, Liang; Zhao, Yuliang; Tan, Weihong
作者单位1.Hunan Univ, Coll Mat Sci & Engn, Aptamer Engn Ctr Hunan Prov,Coll Chem & Chem Engn, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Hunan, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
3.Swinburne Univ Technol, Fac Sci Engn & Technol, Ctr Translat Atomat, Hawthorn, Vic 3122, Australia
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp,Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Inst Mol Med, Shanghai 200240, Peoples R China
7.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China
8.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Cai, Ren,Xiang, Huandong,Yang, Dan,et al. Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2021,143.
APA Cai, Ren.,Xiang, Huandong.,Yang, Dan.,Lin, Keng-Te.,Wu, Yuanzheng.,...&Tan, Weihong.(2021).Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,143.
MLA Cai, Ren,et al."Plasmonic AuPt@CuS Heterostructure with Enhanced Synergistic Efficacy for Radiophotothermal Therapy".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 143(2021).

入库方式： OAI收割

来源：合肥物质科学研究院

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