Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals
文献类型：期刊论文
| 作者 | Zheng,Yuanyuan; Zhang,Fangrong; Xu,Shengmin; Wu,Lijun
|
| 刊名 | Genes and Environment
 |
| 出版日期 | 2021-09-22 |
| 卷号 | 43 |
| 关键词 | CNS hPSC Neural organoids Neurotoxicity testing Environmental chemicals |
| DOI | 10.1186/s41021-021-00214-1 |
| 通讯作者 | Wu,Lijun(ljw@ipp.ac.cn) |
| 英文摘要 | AbstractDue to the complex structure and function of central nervous system (CNS), human CNS in vitro modeling is still a great challenge. Neurotoxicity testing of environmental chemicals mainly depends on the traditional animal models, which have various limitations such as species differences, expensive and time-consuming. Meanwhile, in vitro two-dimensional (2D) cultured cells or three-dimensional (3D) cultured neurospheres cannot fully simulate complex 3D structure of neural tissues. Recent advancements in neural organoid systems provides excellent models for the testing of environmental chemicals that affect the development of human CNS. Neural organoids derived from hPSCs not only can simulate the process of CNS development, including early stage neural tube formation, neuroepithelium differentiation and regional specification, but also its 3D structure, thus can be used to evaluate the effect of chemicals on differentiation and morphogenesis. Here, we provide a review of recent progress in the methods of culturing neural organoids and their applications in neurotoxicity testing of environmental chemicals. We conclude by highlighting challenge and future directions in neurotoxicity testing based on neural organoids. |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S41021-021-00214-1 |
| 出版者 | BioMed Central |
| 源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/125659]  |
| 专题 | 中国科学院合肥物质科学研究院 |
| 通讯作者 | Wu,Lijun |
| 作者单位 | Anhui University; Information Materials and Intelligent Sensing Laboratory of Anhui Province, Institutes of Physical Science and Information Technology |
| 推荐引用方式 GB/T 7714 | Zheng,Yuanyuan,Zhang,Fangrong,Xu,Shengmin,et al. Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals[J]. Genes and Environment,2021,43. |
| APA | Zheng,Yuanyuan,Zhang,Fangrong,Xu,Shengmin,&Wu,Lijun.(2021).Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals.Genes and Environment,43. |
| MLA | Zheng,Yuanyuan,et al."Advances in neural organoid systems and their application in neurotoxicity testing of environmental chemicals".Genes and Environment 43(2021). |
入库方式： OAI收割
来源：合肥物质科学研究院
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