The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study
文献类型：期刊论文
| 作者 | Song, Miaojia1,2; Di, Xiaohui3; Zhang, Yu2 ; Sun, Yongming2; Wang, Zhongming2; Yuan, Zhenhong2; Guo, Ying2
|
| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2021-05-04 |
| 卷号 | 11期号:25页码:15054-15059 |
| DOI | 10.1039/d1ra01780b |
| 通讯作者 | Zhang, Yu(zhangyu@ms.giec.ac.cn) |
| 英文摘要 | As an important bio-based chemical, methyl levulinate (ML) can be produced via enzymatic esterification of levulinic acid with methanol. A kinetic model is developed in this work based on the law of mass action and reaction reversibility, to investigate the effect of enzyme loading, alcohol/acid ratio and temperature on ML yield. Data analysis shows that newly developed binary regression is apparently more persuasive than the commonly used unitary regression. Kinetic study reveals: (1) rate constants of esterification/hydrolysis increase with increasing enzyme loading, while their ratio (equilibrium constant) remains invariant. (2) Methanol has no toxicity towards lipase, and hence, neither the rate constants of esterification/hydrolysis nor the equilibrium constant are affected by alcohol/acid ratio. (3) Both rate constants of esterification/hydrolysis and the equilibrium constant increase with temperature elevation, and their relationships agree with Arrhenius equation and Van't Hoff equation, respectively. (4) The esterification is endothermic and spontaneous. In total, the application of binary regression analysis for the developed model to study the enzymatic esterification kinetics is quite successful. |
| WOS关键词 | LIPASE-CATALYZED ESTERIFICATION ; CANDIDA-ANTARCTICA ; IMMOBILIZATION ; RESOLUTION |
| 资助项目 | National Natural Science Foundation of China[21978288] ; China Scholarship Council[202008440326] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000648718400019 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 资助机构 | National Natural Science Foundation of China ; China Scholarship Council |
| 源URL | [http://ir.giec.ac.cn/handle/344007/33163]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Zhang, Yu |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Guangzhou Inst Energy Convers, CAS Key Lab Renewable Energy, Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou 510640, Peoples R China 3.Univ Strasbourg, CNRS UMR 7177, Strasbourg Inst Chem, Lab Synth Organ React & Catalysis, F-67000 Strasbourg, France |
| 推荐引用方式 GB/T 7714 | Song, Miaojia,Di, Xiaohui,Zhang, Yu,et al. The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study[J]. RSC ADVANCES,2021,11(25):15054-15059. |
| APA | Song, Miaojia.,Di, Xiaohui.,Zhang, Yu.,Sun, Yongming.,Wang, Zhongming.,...&Guo, Ying.(2021).The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study.RSC ADVANCES,11(25),15054-15059. |
| MLA | Song, Miaojia,et al."The effect of enzyme loading, alcohol/acid ratio and temperature on the enzymatic esterification of levulinic acid with methanol for methyl levulinate production: a kinetic study".RSC ADVANCES 11.25(2021):15054-15059. |
入库方式： OAI收割
来源：广州能源研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。