N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source
文献类型：期刊论文
| 作者 | Liu, Jianguo2,3; Song, Yanpei1; Wu, Xiang1; Ma, Longlong1,2
|
| 刊名 | ACS OMEGA
 |
| 出版日期 | 2021-09-07 |
| 卷号 | 6期号:35页码:22504-22513 |
| ISSN号 | 2470-1343 |
| DOI | 10.1021/acsomega.1c01961 |
| 通讯作者 | Liu, Jianguo(liujg@ms.giec.ac.cn) ; Ma, Longlong(mall@rns.giec.ac.cn) |
| 英文摘要 | N-methylated amines are essential bioactive compounds and have been widely used in the fine and bulk chemical industries, as well as in pharmaceuticals, agrochemicals, and dyes. Developing green, efficient, and lowcost catalysts for methylation of amines by using efficient and easily accessible methylating reagents is highly desired yet remains a significant challenge. Herein, we report the selective N-dimethylation of different functional amines with different functional aldehydes under easy-to-handle and industrially applicable conditions using carbon-supported Ru nanoparticles (Ru/C) as a heterogeneous catalyst. A broad spectrum of amines could be efficiently converted to their corresponding N,N-dimethyl amines with good compatibility of various functional groups. This method is widely applicable to N-dimethylation of primary amines including aromatic, aliphatic amines with formaldehyde, and synthesis of tertiary amines from primary, secondary amines with different functional aldehydes. The advantage of this newly described method includes operational simplicity, high turnover number, the ready availability of the catalyst, and good functional group compatibility. This Ru/C catalyzed N-dimethylation reaction possibly proceeds through a two-step N-methylation reaction process. |
| WOS关键词 | REDUCTIVE METHYLATION ; AROMATIC-AMINES ; SECONDARY-AMINES ; FORMIC-ACID ; CHEMOSELECTIVE METHYLATION ; COMPLEX BEARING ; NITRO-COMPOUNDS ; METHANOL ; DIOXIDE ; CO2 |
| 资助项目 | National Key R&D Program of China[2018YFB1501500] ; National Natural Science Foundation of China[51976225] ; DNL Cooperation Fund ; Chinese Academy of Sciences[DNL201916] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000695518100005 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Key R&D Program of China ; National Natural Science Foundation of China ; DNL Cooperation Fund ; Chinese Academy of Sciences |
| 源URL | [http://ir.giec.ac.cn/handle/344007/33899]  |
| 专题 | 中国科学院广州能源研究所 |
| 通讯作者 | Liu, Jianguo; Ma, Longlong |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Renewable Energy, Guangdong Prov Key Lab New & Renewable Energy Res, Guangzhou Inst Energy Convers, Guangzhou 510640, Peoples R China 2.Southeast Univ, Sch Energy & Environm, Minist Educ, Key Lab Energy Thermal Convers & Control, Nanjing 210096, Peoples R China 3.Chinese Acad Sci, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jianguo,Song, Yanpei,Wu, Xiang,et al. N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source[J]. ACS OMEGA,2021,6(35):22504-22513. |
| APA | Liu, Jianguo,Song, Yanpei,Wu, Xiang,&Ma, Longlong.(2021).N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source.ACS OMEGA,6(35),22504-22513. |
| MLA | Liu, Jianguo,et al."N-Dimethylation and N-Functionalization of Amines Using Ru Nanoparticle Catalysts and Formaldehyde or Functional Aldehydes as the Carbon Source".ACS OMEGA 6.35(2021):22504-22513. |
入库方式： OAI收割
来源：广州能源研究所
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