中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors

文献类型:期刊论文

作者Fu, Zening1,9,10; Tu, Yiheng1,10; Calhoun, Vince D.5,6,7,8,9; Zhang, Yuqi1,10; Zhao, Qing1,10; Chen, Jun4; Meng, Qingtao3; Lu, Zhijie2; Hu, Li1,10
刊名NEUROBIOLOGY OF STRESS
出版日期2021-11-01
卷号15页码:10
通讯作者邮箱mengqingtao2018@126.com (q. meng) ; lzjwxyz@163.com (z. lu) ; huli@psych.ac.cn (l. hu)
关键词Coronavirus disease 19 (COVID-19) Post-traumatic stress symptoms (PTSS) Functional magnetic resonance imaging (fMRI) Dynamic functional network connectivity (dFNC) Mental health
ISSN号2352-2895
DOI10.1016/j.ynstr.2021.100377
产权排序1
文献子类实证研究
英文摘要

Accumulating evidence shows that Coronavirus Disease 19 (COVID-19) survivors may encounter prolonged mental issues, especially post-traumatic stress symptoms (PTSS). Despite manifesting a plethora of behavioral or mental issues in COVID-19 survivors, previous studies illustrated that static brain functional networks of these survivors remain intact. The insignificant results could be due to the conventional statistic network analysis was unable to reveal information that can vary considerably in different temporal scales. In contrast, time-varying characteristics of the dynamic functional networks may help reveal important brain abnormalities in COVID19 survivors. To test this hypothesis, we assessed PTSS and collected functional magnetic resonance imaging (fMRI) with COVID-19 survivors discharged from hospitals and matched controls. Results showed that COVID-19 survivors self-reported a significantly higher PTSS than controls. Tapping into the moment-to-moment variations of the fMRI data, we captured the dynamic functional network connectivity (dFNC) states, and three discriminative reoccurring brain dFNC states were identified. First of all, COVID-19 survivors showed an increased occurrence of a dFNC state with heterogeneous patterns between sensorimotor and visual networks. More importantly, the occurrence rate of this state was significantly correlated with the severity of PTSS. Finally, COVID-19 survivors demonstrated decreased topological organizations in this dFNC state than controls, including the node strength, degree, and local efficiency of the supplementary motor area. To conclude, our findings revealed the altered temporal characteristics of functional networks and their associations with PTSS due to COVID-19. The current results highlight the importance of evaluating dynamic functional network changes with COVID-19 survivors.

收录类别SCI
WOS关键词BRAIN ; DEPRESSION ; DISORDER ; ANXIETY
资助项目National Natural Science Foundation of China[31822025] ; National Natural Science Foundation of China[32071061] ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences[E0CX521003] ; Medical Science and Technology Youth Cultivation Project of PLA[21QNPY061] ; National Institutes of Health (NIH)[R01EB006841] ; National Institutes of Health (NIH)[R01EB020407] ; National Institutes of Health (NIH)[P20GM103472]
WOS研究方向Neurosciences & Neurology
WOS记录号WOS:000702921700007
出版者ELSEVIER SCIENCE INC
资助机构National Natural Science Foundation of China ; Scientific Foundation of Institute of Psychology, Chinese Academy of Sciences ; Medical Science and Technology Youth Cultivation Project of PLA ; National Institutes of Health (NIH)
源URL[http://ir.psych.ac.cn/handle/311026/40357]  
专题心理研究所_中国科学院心理健康重点实验室
中国科学院心理研究所
通讯作者Meng, Qingtao; Lu, Zhijie; Hu, Li
作者单位1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Second Mil Med Univ, Affiliated Hosp 3, Dept Anesthesiol, Shanghai 200438, Peoples R China
3.Wuhan Univ, Renmin Hosp, Dept Anesthesiol, Wuhan 430060, Peoples R China
4.Wuhan Univ, Renmin Hosp, Dept Radiol, Wuhan 430060, Peoples R China
5.Georgia Inst Technol, Dept Elect & Comp Engn, Atlanta, GA 30332 USA
6.Georgia State Univ, Phys, Atlanta, GA 30303 USA
7.Georgia State Univ, Dept Psychol, Neurosci Inst, Comp Sci, Univ Plaza, Atlanta, GA 30303 USA
8.Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
9.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA
10.Univ Chinese Acad Sci, Dept Psychol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Fu, Zening,Tu, Yiheng,Calhoun, Vince D.,et al. Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors[J]. NEUROBIOLOGY OF STRESS,2021,15:10.
APA Fu, Zening.,Tu, Yiheng.,Calhoun, Vince D..,Zhang, Yuqi.,Zhao, Qing.,...&Hu, Li.(2021).Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors.NEUROBIOLOGY OF STRESS,15,10.
MLA Fu, Zening,et al."Dynamic functional network connectivity associated with post-traumatic stress symptoms in COVID-19 survivors".NEUROBIOLOGY OF STRESS 15(2021):10.

入库方式: OAI收割

来源:心理研究所

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