Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis
文献类型:期刊论文
作者 | Wang, Ya2,3,4; Braam, Esmee E.2,3; Wannan, Cassandra M. J.2,3; Van Rheenen, Tamsyn E.2,3,5; Chan, Raymond C. K.4; Nelson, Barnaby6,7; McGorry, Patrick D.6,7; Yung, Alison R.6,7,8,12; Lin, Ashleigh9; Brewer, Warrick J.7 |
刊名 | EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE |
出版日期 | 2021-08-31 |
页码 | 11 |
ISSN号 | 0940-1334 |
关键词 | Neurological soft signs Ultra-high risk Grey matter volume Voxel-based morphometry Transition |
DOI | 10.1007/s00406-021-01300-9 |
通讯作者 | Cropley, Vanessa L.(vcropley@unimelb.edu.au) |
英文摘要 | Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebello-thalamo-cortical structures, but it is unclear whether similar structures underlie NSS prior to the onset of psychosis. The present study investigated the relationship between severity of NSS and grey matter volume (GMV) in individuals at ultra-high risk for psychosis (UHR) stratified for later conversion to psychosis. Structural T1-weighted MRI scans were obtained from 56 antipsychotic-naive UHR individuals and 35 healthy controls (HC). The UHR individuals had follow-up data (mean follow-up: 5.2 years) to ascertain clinical outcome. Using whole-brain voxel-based morphometry, the relationship between NSS and GMV at baseline was assessed in UHR, HC, as well as individuals who later transitioned (UHR-P, n = 25) and did not transition (UHR-NP, n = 31) to psychosis. NSS total and subscale scores except motor coordination were significantly higher in UHR compared to HC. Higher signs were also found in UHR-P, but not UHR-NP. Total NSS was not associated with GMV in the whole sample or in each group. However, in UHR-P individuals, greater deficits in sensory integration was associated with lower GMV in the left cerebellum, right insula, and right middle frontal gyrus. In conclusion, NSS are present in UHR individuals, particularly those who later transitioned to a psychotic disorder. While these signs show little overall variation with GMV, the association of sensory integration deficits with lower GMV in UHR-P suggests that certain brain areas may be implicated in the development of specific neurological abnormalities in the psychosis prodrome. |
收录类别 | SCI |
WOS关键词 | CLINICAL HIGH-RISK ; AT-RISK ; NEUROANATOMICAL ABNORMALITIES ; CEREBELLAR VOLUME ; TRANSITION RATE ; FOLLOW-UP ; SCHIZOPHRENIA ; ONSET ; DYSFUNCTION ; REDUCTION |
资助项目 | National Health and Medical Research Council (NHMRC), Australia[970598] ; National Health and Medical Research Council (NHMRC), Australia[981112] ; National Health and Medical Research Council (NHMRC), Australia[350241] ; Ian Potter Foundation, Melbourne ; Woods Family Trust, Melbourne ; Victorian Health Promotion Foundation, Melbourne ; NHMRC Senior Principal Research Fellowships[628386] ; NHMRC Senior Principal Research Fellowships[1105825] ; Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award[18722] ; NHMRC Senior Principal Research Fellowship ; Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US) ; NHMRC Principal Research Fellowship[1136829] ; National Institute of Health Research (NIHR) Senior Fellowship Award ; China Scholarship Council ; NHMRC Early Career Fellowship[1088785] ; NHMRC Senior Research Fellowship[1137687] ; NHMRC Career Development Fellowship[1148793] ; NHMRC Investigator Grant[1177370] ; Brain and Behavior Research Foundation (NARSAD) Young Investigator Award[21660] ; University of Melbourne Dame Kate Campbell Fellowship ; National Key Research and Development Programme[2016YFC0906402] |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | SPRINGER HEIDELBERG |
WOS记录号 | WOS:000691637000001 |
资助机构 | National Health and Medical Research Council (NHMRC), Australia ; Ian Potter Foundation, Melbourne ; Woods Family Trust, Melbourne ; Victorian Health Promotion Foundation, Melbourne ; NHMRC Senior Principal Research Fellowships ; Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award ; NHMRC Senior Principal Research Fellowship ; Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US) ; NHMRC Principal Research Fellowship ; National Institute of Health Research (NIHR) Senior Fellowship Award ; China Scholarship Council ; NHMRC Early Career Fellowship ; NHMRC Senior Research Fellowship ; NHMRC Career Development Fellowship ; NHMRC Investigator Grant ; Brain and Behavior Research Foundation (NARSAD) Young Investigator Award ; University of Melbourne Dame Kate Campbell Fellowship ; National Key Research and Development Programme |
源URL | [http://ir.psych.ac.cn/handle/311026/40157] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Cropley, Vanessa L. |
作者单位 | 1.Royal Melbourne Hosp, Melbourne Hlth, Neuropsychiat Unit, Melbourne, Vic, Australia 2.Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Level 3,Alan Gilbert Bldg,161 Barry St, Melbourne, Vic 3053, Australia 3.Melbourne Hlth, Level 3,Alan Gilbert Bldg,161 Barry St, Melbourne, Vic 3053, Australia 4.Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 5.Swinburne Univ, Sch Hlth Sci, Fac Hlth Arts & Design, Ctr Mental Hlth, Melbourne, Vic, Australia 6.Orygen, Melbourne, Vic, Australia 7.Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia 8.Univ Manchester, Sch Hlth Sci, Manchester, Lancs, England 9.Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia 10.Univ Birmingham, Sch Psychol, Edgbaston, England |
推荐引用方式 GB/T 7714 | Wang, Ya,Braam, Esmee E.,Wannan, Cassandra M. J.,et al. Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis[J]. EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,2021:11. |
APA | Wang, Ya.,Braam, Esmee E..,Wannan, Cassandra M. J..,Van Rheenen, Tamsyn E..,Chan, Raymond C. K..,...&Cropley, Vanessa L..(2021).Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis.EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE,11. |
MLA | Wang, Ya,et al."Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis".EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE (2021):11. |
入库方式: OAI收割
来源:心理研究所
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