Comorbid major depression in first-episode drug-naive patients with schizophrenia: Analysis of the Depression in Schizophrenia in China (DISC) study
文献类型:期刊论文
作者 | Li, Zezhi7; Xue, Mei8; Zhao, Lei8; Zhou, Yongjie1; Wu, Xi5; Xie, Xiaoxian6; Lang, Xiaoe3; Zhang, Xiangyang2,4 |
刊名 | JOURNAL OF AFFECTIVE DISORDERS |
出版日期 | 2021-11-01 |
卷号 | 294页码:33-38 |
通讯作者邮箱 | zhangxy@psych.ac.cn (x. zhang) |
ISSN号 | 0165-0327 |
关键词 | Depression Schizophrenia Comorbidity Prevalence Associated factor1 |
DOI | 10.1016/j.jad.2021.06.075 |
产权排序 | 7 |
文献子类 | 实证研究 |
英文摘要 | Background: Depression is very common in patients with schizophrenia, but few studies have investigated the diagnosed major depressive episode (MDE) in first episode and drug naive (FEDN) schizophrenia. To our best knowledge, this is the first large sample study to examine the prevalence, clinical correlates and associated factors of diagnosed MDE in FEDN schizophrenia, as well as the relationship between depressive symptoms and psychopathological symptoms in these schizophrenia patients. Methods: A total of 996 FEDN schizophrenia patients were recruited. The 17-item Hamilton Depression Rating Scale (HAMD17) and Positive and Negative Syndrome Scale (PANSS) were used to assess the severity of depression and psychopathology, respectively. Results: Our results demonstrated that MDE coexisted in nearly half (49.30%) of FEDN schizophrenia patients. Male gender, smoking, PANSS general psychopathology and early age of onset were associated with MDE in patients with FEDN schizophrenia (all p<0.05). In schizophrenia patients with MDE, oridinal logistic regression showed that men (OR=6.65, 95%CI: 4.12-10.45, p<0.001) and smoking (OR=1.94, 95%CI: 1.25-3.01, p=0.003) were positively associated with severity category of depression (all p<0.05), while multivariate regression showed that HAMD17 total score was significantly associated with the PANSS general psychopathology (B=0.06, t=2.72, p=0.007) and total scores (B=0.04, t=2.57, p=0.01). Conclusion: Our study shows that the prevalence of comorbid MDE is high in FEDN schizophrenia patients. Some demographic and clinical variables are associated with the severity of depression in these schizophrenia patients. |
收录类别 | SCI |
WOS关键词 | PSYCHIATRIC-DISORDERS ; CIGARETTE-SMOKING ; NEGATIVE SYMPTOMS ; BIPOLAR DISORDER ; HIGH-RISK ; ASSOCIATION ; EPISODE ; PREVALENCE ; PSYCHOSIS ; VARIANTS |
资助项目 | Shanghai Jiao Tong University Medical Engineering Foundation[YG2016MS48] ; Shanghai Jiao Tong University School of Medicine[19XJ11006] |
WOS研究方向 | Neurosciences & Neurology ; Psychiatry |
出版者 | ELSEVIER |
WOS记录号 | WOS:000691677100005 |
资助机构 | Shanghai Jiao Tong University Medical Engineering Foundation ; Shanghai Jiao Tong University School of Medicine |
源URL | [http://ir.psych.ac.cn/handle/311026/40189] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Zhang, Xiangyang |
作者单位 | 1.Shenzhen Kangning Hosp, Shenzhen, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Shanxi Med Univ, Clin Med Coll 1, Dept Psychiat, Taiyuan, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Shanghai Changhai Hosp, Dept Neurosurg, Shanghai, Peoples R China 6.Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou, Peoples R China 7.Guangzhou Med Univ, Affiliated Brain Hosp, Dept Psychiat, Guangzhou, Peoples R China 8.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Zezhi,Xue, Mei,Zhao, Lei,et al. Comorbid major depression in first-episode drug-naive patients with schizophrenia: Analysis of the Depression in Schizophrenia in China (DISC) study[J]. JOURNAL OF AFFECTIVE DISORDERS,2021,294:33-38. |
APA | Li, Zezhi.,Xue, Mei.,Zhao, Lei.,Zhou, Yongjie.,Wu, Xi.,...&Zhang, Xiangyang.(2021).Comorbid major depression in first-episode drug-naive patients with schizophrenia: Analysis of the Depression in Schizophrenia in China (DISC) study.JOURNAL OF AFFECTIVE DISORDERS,294,33-38. |
MLA | Li, Zezhi,et al."Comorbid major depression in first-episode drug-naive patients with schizophrenia: Analysis of the Depression in Schizophrenia in China (DISC) study".JOURNAL OF AFFECTIVE DISORDERS 294(2021):33-38. |
入库方式: OAI收割
来源:心理研究所
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