The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia
文献类型：期刊论文
| 作者 | Cao, Haiyan4; Zhou, Yongjie1; Li, Tao4; Yao, Cong4; Yang, Weiliang4; Kong, Siying4; Wang, Yanyan4; Yu, Baoping4; Jiao, Qingyan4; Sun, Yun4 |
| 刊名 | FRONTIERS IN PSYCHIATRY
 |
| 出版日期 | 2021-08-16 |
| 卷号 | 12页码:11 |
| 关键词 | schizophrenia antipsychotics QTc prolongation Chinese prevalence risk factor clinical correlates |
| ISSN号 | 1664-0640 |
| DOI | 10.3389/fpsyt.2021.704045 |
| 通讯作者 | Zhang, Xiangyang(zhangxy@psych.ac.cn) ; Li, Jie(jieli@tjmhc.com) |
| 英文摘要 | Background: The QTc interval may be significantly prolonged in schizophrenia patients taking antipsychotics. Few studies have addressed QTc prolongation (QTP) in Chinese patients. & nbsp; Objectives: This study was designed to evaluate the prevalence of QTP and its clinical correlates in Chinese hospitalized patients with chronic schizophrenia. & nbsp; Methods: A total of 436 inpatients and 291 normal controls matched with age and sex were included. QTc prolongation was defined as 2 standard deviations (SD) above the mean value of normal controls. Positive and Negative Syndrome Scale (PANSS) and its five-factor model were used to evaluate psychopathological symptoms. & nbsp; Results: QTc interval was significantly longer in patients than in normal controls. The prevalence of QTP is 8.26% in Chinese hospitalized patients with chronic schizophrenia. More women than men displayed QTP. Compared with patients without QTP, the patients with QTP had significantly higher concrete/disorganized subscore, lower low density lipoprotein (LDL) and lower total protein (TP). Furthermore, binary logistic regression analysis showed that higher number of hospitalizations, higher concrete/disorganized subscore and lower LDL were risk factors for QTP. Correlation analysis indicated significant association between QTc interval and the following variables: sex, age, duration of illness, the number of hospitalizations, PANSS total score, fasting blood glucose (FPG). Finally, a multiple regression analysis showed that older age, antipsychotic polypharmacy, higher PANSS total score, and lower LDL were risk factors for QTP. Among them, LDL seemed to be a protective factor for QTP. & nbsp; Conclusions: QTc interval was longer in schizophrenia patients than in normal controls. The prevalence of QTP is 8.26% in Chinese hospitalized patients with chronic schizophrenia. Some clinical characteristics were risk factors for QTP. And LDL seemed to be a protective factor for QTP. |
| 收录类别 | SCI |
| WOS关键词 | NEGATIVE SYNDROME SCALE ; INTERVAL PROLONGATION ; ANTIPSYCHOTIC-DRUGS ; 5-FACTOR MODEL ; DE-POINTES ; KCNH2 ; GENE ; ELECTROCARDIOGRAM ; REPOLARIZATION ; ADOLESCENTS |
| 资助项目 | National Key R&D Program of China by Ministry of Science and Technology of China[2016YFC1306800] ; Tianjin Key Project for Chronic Diseases Prevention by Tianjin Municipal Science and Technology Bureau[2017ZXMFSY00070] ; Tianjin Key Discipline for Psychiatry |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000693099000001 |
| 出版者 | FRONTIERS MEDIA SA |
| 资助机构 | National Key R&D Program of China by Ministry of Science and Technology of China ; Tianjin Key Project for Chronic Diseases Prevention by Tianjin Municipal Science and Technology Bureau ; Tianjin Key Discipline for Psychiatry |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40200]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Zhang, Xiangyang; Li, Jie |
| 作者单位 | 1.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, Shenzhen, Peoples R China 2.Jining Psychiat Hosp, Dept Psychiat, Jining, Peoples R China 3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 4.Tianjin Med Univ, Inst Mental Hlth, Tianjin Anding Hosp, Tianjin, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Haiyan,Zhou, Yongjie,Li, Tao,et al. The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia[J]. FRONTIERS IN PSYCHIATRY,2021,12:11. |
| APA | Cao, Haiyan.,Zhou, Yongjie.,Li, Tao.,Yao, Cong.,Yang, Weiliang.,...&Li, Jie.(2021).The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia.FRONTIERS IN PSYCHIATRY,12,11. |
| MLA | Cao, Haiyan,et al."The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia".FRONTIERS IN PSYCHIATRY 12(2021):11. |
入库方式： OAI收割
来源：心理研究所
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