The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study
文献类型：期刊论文
| 作者 | Liu, Jiahong5; Wang, Pingping4; Sun, Leilei3; Guan, Xiaoni1; Xiu, Meihong1; Zhang, Xiangyang2
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| 刊名 | TRANSLATIONAL PSYCHIATRY
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| 出版日期 | 2021-09-04 |
| 卷号 | 11期号:1页码:5 |
| ISSN号 | 2158-3188 |
| DOI | 10.1038/s41398-021-01585-3 |
| 通讯作者 | Xiu, Meihong(xiumeihong9797@gmail.com) ; Zhang, Xiangyang(zhangxy@psych.ac.cn) |
| 英文摘要 | A growing number of studies have shown that brain-derived neurotrophic factor (BDNF) is associated with weight gain during antipsychotic treatment in schizophrenia patients. However, there is still a lack of research results in the initial stage of antipsychotic treatment. This study aimed to evaluate the relationship between weight gain caused by risperidone monotherapy for 12 weeks and BDNF level in antipsychotic-naive and first-episode (ANFE) patients with schizophrenia, and we hypothesize that this may depend on BDNF Val66Met gene polymorphism. In a 12-week longitudinal trial, 225 ANFE patients were enrolled and treated with risperidone. Body weight was measured at baseline and during the 12-week follow-up. After treatment, the average weight of ANFE patients increased by 2.6 kg. Furthermore, we found that in patients with Val/Val genotype, the increase in serum BDNF levels was negatively correlated with risperidone-induced weight gain (r = -0.44, p = 0.008). Regression analysis showed that the baseline BDNF level was a predictor of weight gain after treatment (beta = -0.45, t = -3.0, p = 0.005). Our results suggest that the BDNF signaling may be involved in weight gain caused by risperidone treatment. Furthermore, the negative association between weight gain and increased BDNF levels during risperidone treatment in ANFE schizophrenia depends on the BDNF Val66Met polymorphism. |
| 收录类别 | SCI |
| WOS关键词 | NEUROTROPHIC FACTOR BDNF ; BODY-MASS INDEX ; GENE POLYMORPHISMS ; DEFICIENT ; VARIANTS ; CHILDREN ; RECEPTOR ; OBESITY ; DRUGS |
| WOS研究方向 | Psychiatry |
| 语种 | 英语 |
| WOS记录号 | WOS:000693037500003 |
| 出版者 | SPRINGERNATURE |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40212]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Xiu, Meihong; Zhang, Xiangyang |
| 作者单位 | 1.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Qingdao Univ, Qingdao Mental Hlth Ctr, Qingdao, Peoples R China 4.Capital Med Univ, Dept Neurol, Xuan Wu Hosp, Beijing, Peoples R China 5.Wenzhou Med Univ, Affiliated Kangning Hosp, Wenzhou, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jiahong,Wang, Pingping,Sun, Leilei,et al. The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study[J]. TRANSLATIONAL PSYCHIATRY,2021,11(1):5. |
| APA | Liu, Jiahong,Wang, Pingping,Sun, Leilei,Guan, Xiaoni,Xiu, Meihong,&Zhang, Xiangyang.(2021).The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study.TRANSLATIONAL PSYCHIATRY,11(1),5. |
| MLA | Liu, Jiahong,et al."The association between BDNF levels and risperidone-induced weight gain is dependent on the BDNF Val66Met polymorphism in antipsychotic-naive first episode schizophrenia patients: a 12-week prospective study".TRANSLATIONAL PSYCHIATRY 11.1(2021):5. |
入库方式： OAI收割
来源：心理研究所
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