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Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report

文献类型：期刊论文

作者Guo, Liyuan1,3; Ren, Haitao2; Fan, Siyuan2; Guan, Hongzhi2; Wang, Jing1,3
刊名JOURNAL OF NEUROIMMUNOLOGY
出版日期2021-10-15
卷号359页码:7
通讯作者邮箱guanhz@263.net (h. guan) ; wangjing@psych.ac.cn (j. wang)
关键词Autoimmune Cerebellar ataxia Novel autoantibody Anti-Rab6A Rab6B antibody
ISSN号0165-5728
DOI10.1016/j.jneuroim.2021.577667
产权排序1
文献子类评论
英文摘要

In the current study we report a novel autoantibody against Purkinje cells in a patient with primary autoimmune cerebellar ataxia (PACA) associated with Sjogren's syndrome (SS). Tissue-based indirect immunofluorescence assay (TBA) of the patient's serum and cerebrospinal fluid (CSF) revealed IgG antibody to Purkinje cells and the granular layer of the rat cerebellum. Rab6A was identified as autoantigen by mass spectrometry (MS) and Western blotting, and the interactions between Rab6A or its homologous Rab6B and autoantibody in patient serum were verified by recombinant cell-based assay (CBA) and neutralization experiments. This autoantibody may represent a novel biomarker in the diagnosis of PACA.

收录类别SCI
WOS关键词MUTATIONS ; DISEASE ; WEAKNESS
资助项目National Key Research and Develop-ment Program of China[2016YFC0901500] ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
WOS研究方向Immunology ; Neurosciences & Neurology
语种英语
WOS记录号WOS:000695211500008
出版者ELSEVIER
资助机构National Key Research and Develop-ment Program of China ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences
源URL[http://ir.psych.ac.cn/handle/311026/40235]  
专题心理研究所_中国科学院心理健康重点实验室
通讯作者Guan, Hongzhi; Wang, Jing
作者单位1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China
2.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Neurol, Beijing, Peoples R China
3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Liyuan,Ren, Haitao,Fan, Siyuan,et al. Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report[J]. JOURNAL OF NEUROIMMUNOLOGY,2021,359:7.
APA Guo, Liyuan,Ren, Haitao,Fan, Siyuan,Guan, Hongzhi,&Wang, Jing.(2021).Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report.JOURNAL OF NEUROIMMUNOLOGY,359,7.
MLA Guo, Liyuan,et al."Autoantibody against the Rab6A/Rab6B in primary autoimmune cerebellar ataxia associated with Sjogren's syndrome: A case report".JOURNAL OF NEUROIMMUNOLOGY 359(2021):7.

入库方式： OAI收割

来源：心理研究所

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