Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia
文献类型：期刊论文
| 作者 | Guneri, Sinem1,2,3; Scheel-Kruger, Jorgen1,4; Luo, Fei1,2,3
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| 刊名 | BEHAVIOURAL PHARMACOLOGY
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| 出版日期 | 2021-10-01 |
| 卷号 | 32期号:7页码:571-580 |
| 关键词 | acute pain complete Freund's adjuvant chronic pain formalin MK-801 rodent model schizophrenia spontaneous pain |
| ISSN号 | 0955-8810 |
| DOI | 10.1097/FBP.0000000000000651 |
| 通讯作者 | Luo, Fei(luof@psych.ac.cn) |
| 英文摘要 | Patients diagnosed with schizophrenia have been reported to exhibit atypically low pain sensitivity and to vary in their experience of chronic pain. To the best of our knowledge, there has yet to be an animal study that provides information concerning the relationship between models of schizophrenia and pain. In the present study, we investigated several distinct nociceptive behaviors in a translational rat model of schizophrenia (0. 5 mg/kg MK-801, twice a day for 7 days followed by a 7-day washout period). The presence of the expected cognitive deficit was confirmed with novel object recognition (NOR) paradigm prior to nociception testing. MK-801-treated rats with lack of novelty interest in NOR testing showed: hyposensitivity to thermal and mechanical stimuli; short-term hypoalgesia followed by augmented hyperalgesia in response to formalin-induced spontaneous nociception and increased thermal and mechanical hyperalgesia in the complete Freund's adjuvant (CFA) induced chronic pain model. In conclusion, MK-801 induced antinociception effects for thermal stimuli in rats that were consistent with the decreased pain sensitivity observed in schizophrenia patients. Additionally, the amplified biphasic response exhibited by the MK-801 group in the formalin-induced spontaneous nociception test affirms the suitability of the test as a model of acute to delayed pain transition. |
| 收录类别 | SCI |
| WOS关键词 | NMDA-RECEPTOR ANTAGONIST ; FORMALIN TEST ; OBJECT RECOGNITION ; ANIMAL-MODEL ; SOCIAL-ISOLATION ; PAIN PERCEPTION ; MK-801 ; PHENCYCLIDINE ; KETAMINE ; HYPERALGESIA |
| 资助项目 | NNSF[31970926] |
| WOS研究方向 | Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000695678500004 |
| 出版者 | LIPPINCOTT WILLIAMS & WILKINS |
| 资助机构 | NNSF |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40273]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Luo, Fei |
| 作者单位 | 1.Sino Danish Ctr Educ & Res, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, 4A Datun Rd, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China 4.Aarhus Univ, Ctr Funct Integrat Neurosci, Dept Clin Med, Aarhus, Denmark |
| 推荐引用方式 GB/T 7714 | Guneri, Sinem,Scheel-Kruger, Jorgen,Luo, Fei. Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia[J]. BEHAVIOURAL PHARMACOLOGY,2021,32(7):571-580. |
| APA | Guneri, Sinem,Scheel-Kruger, Jorgen,&Luo, Fei.(2021).Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia.BEHAVIOURAL PHARMACOLOGY,32(7),571-580. |
| MLA | Guneri, Sinem,et al."Evaluation of acute and chronic nociception in subchronically administered MK-801-induced rat model of schizophrenia".BEHAVIOURAL PHARMACOLOGY 32.7(2021):571-580. |
入库方式： OAI收割
来源：心理研究所
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