Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms
文献类型：期刊论文
| 作者 | Teng, Guixiang1,6; Zhang, Fengrui2,3; Li, Zhenjiang4; Zhang, Chun5; Zhang, Libo2,3; Chen, Lele1,6; Zhou, Tao1,6; Yue, Lupeng2,3; Zhang, Ji1,6 |
| 刊名 | NEUROSCIENCE BULLETIN
 |
| 出版日期 | 2021-09-22 |
| 页码 | 15 |
| ISSN号 | 1673-7067 |
| 关键词 | Electrocorticogram Analgesic effect Lappaconitine derivatives Antinociceptive mechanisms Laser-evoked potentials |
| DOI | 10.1007/s12264-021-00774-w |
| 通讯作者 | Yue, Lupeng(yuelp@psych.ac.cn) ; Zhang, Ji(zhangj@nwnu.edu.cn) |
| 英文摘要 | Quantitative evaluation of analgesic efficacy improves understanding of the antinociceptive mechanisms of new analgesics and provides important guidance for their development. Lappaconitine (LA), a potent analgesic drug extracted from the root of natural Aconitum species, has been clinically used for years because of its effective analgesic and non-addictive properties. However, being limited to ethological experiments, previous studies have mainly investigated the analgesic effect of LA at the behavioral level, and the associated antinociceptive mechanisms are still unclear. In this study, electrocorticogram (ECoG) technology was used to investigate the analgesic effects of two homologous derivatives of LA, Lappaconitine hydrobromide (LAH) and Lappaconitine trifluoroacetate (LAF), on Sprague-Dawley rats subjected to nociceptive laser stimuli, and to further explore their antinociceptive mechanisms. We found that both LAH and LAF were effective in reducing pain, as manifested in the remarkable reduction of nocifensive behaviors and laser-evoked potentials (LEPs) amplitudes (N2 and P2 waves, and gamma-band oscillations), and significantly prolonged latencies of the LEP-N2/P2. These changes in LEPs reflect the similar antinociceptive mechanism of LAF and LAH, i.e., inhibition of the fast signaling pathways. In addition, there were no changes in the auditory-evoked potential (AEP-N1 component) before and after LAF or LAH treatment, suggesting that neither drug had a central anesthetic effect. Importantly, compared with LAH, LAF was superior in its effects on the magnitudes of gamma-band oscillations and the resting-state spectra, which may be associated with their differences in the octanol/water partition coefficient, degree of dissociation, toxicity, and glycine receptor regulation. Altogether, jointly applying nociceptive laser stimuli and ECoG recordings in rats, we provide solid neural evidence for the analgesic efficacy and antinociceptive mechanisms of derivatives of LA. |
| 收录类别 | SCI |
| WOS关键词 | PRIMARY SOMATOSENSORY CORTEX ; CORTICAL RESPONSES ; FIELD POTENTIALS ; CHRONIC PAIN ; EEG ; STIMULATION ; CONTRIBUTES ; TOUCH ; OSCILLATIONS ; REFLECT |
| 资助项目 | National Natural Science Foundation of China[51873175] ; Special Fund of Guiding Scientific and Technological Innovation and Development in Gansu Province, China[2019ZX-05] |
| WOS研究方向 | Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | SPRINGER |
| WOS记录号 | WOS:000698312500001 |
| 资助机构 | National Natural Science Foundation of China ; Special Fund of Guiding Scientific and Technological Innovation and Development in Gansu Province, China |
| 源URL | [http://ir.psych.ac.cn/handle/311026/40279]  |
| 专题 | 心理研究所_中国科学院心理健康重点实验室 |
| 通讯作者 | Yue, Lupeng; Zhang, Ji |
| 作者单位 | 1.Northwest Normal Univ, Rural Dev Acad, Lanzhou 730070, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 4.Jiangxi Normal Univ, Sch Psychol, Nanchang 330022, Jiangxi, Peoples R China 5.Lanzhou Jiaotong Univ, Sch Chem & Biol Engn, Lanzhou 730070, Peoples R China 6.Northwest Normal Univ, Coll Life Sci, Lanzhou 730070, Peoples R China |
| 推荐引用方式 GB/T 7714 | Teng, Guixiang,Zhang, Fengrui,Li, Zhenjiang,et al. Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms[J]. NEUROSCIENCE BULLETIN,2021:15. |
| APA | Teng, Guixiang.,Zhang, Fengrui.,Li, Zhenjiang.,Zhang, Chun.,Zhang, Libo.,...&Zhang, Ji.(2021).Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms.NEUROSCIENCE BULLETIN,15. |
| MLA | Teng, Guixiang,et al."Quantitative Electrophysiological Evaluation of the Analgesic Efficacy of Two Lappaconitine Derivatives: A Window into Antinociceptive Drug Mechanisms".NEUROSCIENCE BULLETIN (2021):15. |
入库方式： OAI收割
来源：心理研究所
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